Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
Clin Endocrinol (Oxf). 2011 Mar;74(3):294-9. doi: 10.1111/j.1365-2265.2010.03922.x.
Both resistin and vitamin D have been associated with the renin-angiotensin-aldosterone system (RAAS). We investigated the association between resistin and the RAAS, and resistin and vitamin D under controlled dietary sodium conditions.
Retrospective cross-sectional study of subjects from the HyperPATH Consortium, who were maintained in high dietary sodium (HS) and low dietary sodium (LS) balance for 1 week each.
Caucasian subjects with hypertension (n=177).
25-Hydroxyvitamin D (25[OH]D) levels were used to assess vitamin D status. Plasma resistin and RAAS measures were evaluated on each dietary intervention.
Resistin levels were significantly higher in LS, where RAAS activity was high, when compared with HS balance, where RAAS activity was suppressed (6.36 vs 5.86 μg/l, P < 0.0001); however, resistin concentrations were not associated with plasma renin activity or serum aldosterone on either diet. 25(OH)D levels were positively and independently associated with resistin in both dietary conditions (HS: β=0.400, P-trend=0.027; LS: β=0.540, P-trend=0.014).
Dietary sodium loading reduced resistin levels, possibly by suppressing the RAAS; however, circulating RAAS components were not related to resistin concentrations within each specific dietary sodium condition. 25(OH)D was positively associated with resistin and may be involved in resistin regulation through an unknown mechanism. Further studies to understand resistin regulation in human hypertension better are warranted.
抵抗素和维生素 D 均与肾素-血管紧张素-醛固酮系统（RAAS）有关。我们研究了在控制饮食钠条件下抵抗素与 RAAS 以及抵抗素与维生素 D 之间的关系。
对 HyperPATH 联盟的受试者进行回顾性横断面研究，这些受试者在高（HS）和低（LS）饮食钠平衡状态下分别维持 1 周。
高血压的白种人受试者（n=177）。
用 25-羟维生素 D（25[OH]D）水平评估维生素 D 状况。在每种饮食干预下评估血浆抵抗素和 RAAS 指标。
与 HS 平衡时 RAAS 活性受到抑制相比，LS 时 RAAS 活性较高，抵抗素水平明显升高（6.36 与 5.86 μg/l，P<0.0001）；然而，在两种饮食条件下，抵抗素浓度均与血浆肾素活性或血清醛固酮无关。在两种饮食条件下，25（OH）D 水平与抵抗素均呈正相关且独立相关（HS：β=0.400，P-trend=0.027；LS：β=0.540，P-trend=0.014）。
饮食钠负荷降低了抵抗素水平，可能是通过抑制 RAAS；然而，在每种特定饮食钠条件下，循环 RAAS 成分与抵抗素浓度无关。25（OH）D 与抵抗素呈正相关，可能通过未知机制参与抵抗素的调节。需要进一步的研究来更好地了解人类高血压中抵抗素的调节。
