Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, Texas 78245, USA.
J Infect Dis. 2010 May 1;201(9):1326-30. doi: 10.1086/651562.
In western Cambodia, malaria parasites clear slowly from the blood after treatment with artemisinin derivatives, but it is unclear whether this results from parasite, host, or other factors specific to this population. We measured heritability of clearance rate by evaluating patients infected with identical or nonidentical parasite genotypes, using methods analogous to human twin studies. A substantial proportion (56%-58%) of the variation in clearance rate is explained by parasite genetics. This has 2 important implications: (1) selection with artemisinin derivatives will tend to drive resistance spread and (2) because heritability is high, the genes underlying parasite clearance rate may be identified by genome-wide association.
在柬埔寨西部，青蒿素衍生物治疗后疟原虫从血液中清除缓慢，但尚不清楚这是由于寄生虫、宿主还是该人群特有的其他因素所致。我们通过评估感染相同或不同寄生虫基因型的患者，使用类似于人类双胞胎研究的方法，来衡量清除率的遗传性。清除率的变异有相当一部分（56%-58%）由寄生虫遗传学解释。这有两个重要的含义：（1）用青蒿素衍生物进行选择往往会导致耐药性传播；（2）由于遗传性高，清除率相关的基因可以通过全基因组关联来识别。
