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重症监护病房内外行机械通气的老年患者:579 例通气的对比前瞻性研究。

Elderly patients undergoing mechanical ventilation in and out of intensive care units: a comparative, prospective study of 579 ventilations.

机构信息

The Pulmonary Unit, The Soroka University Medical Center, Beer-Sheva, Israel.

出版信息

Crit Care. 2010;14(2):R48. doi: 10.1186/cc8935. Epub 2010 Mar 30.

Abstract

INTRODUCTION

Many mechanically ventilated elderly patients in Israel are treated outside of intensive care units (ICUs). The decision as to whether these patients should be treated in ICUs is reached without clear guidelines. We therefore conducted a study with the aim of identifying triage criteria and factors associated with in-hospital mortality in this population.

METHODS

All mechanically invasive ventilated elderly (65+) medical patients in the hospital were included in a prospective, non-interventional, observational study.

RESULTS

Of the 579 ventilations, 283 (48.9%) were done in ICUs compared with 296 (51.1%) in non-ICU wards. The percentage of ICU ventilations in the 65 to 74, 75 to 84, and 85+ age groups was 62%, 45%, and 23%, respectively. The decision to ventilate in ICUs was significantly and independently influenced by age (Odds Ratio (OR) = 0.945, P < 0.001), and pre-hospitalization functional status by functional independence measure (FIM) scale (OR = 1.054, P < 0.001). In-hospital mortality was 53.0% in ICUs compared with 68.2% in non-ICU wards (P < 0.001), but the rate was not independently and significantly affected by hospitalization in ICUs.

CONCLUSIONS

In Israel, most elderly patients are ventilated outside ICUs and the percentage of ICU ventilations decreases as age increases. In our study groups, the lower mortality among elderly patients ventilated in ICUs is related to patient characteristics and not to their treatment in ICUs per se. Although the milieu in which this study was conducted is uncommon today in the western world, its findings point to possible means of managing future situations in which the demand for mechanical ventilation of elderly patients exceeds the supply of intensive care beds. Moreover, the findings of this study can contribute to the search for ways to reduce costs without having a negative effect on outcome in ventilated elderly patients.

摘要

引言

在以色列,许多接受机械通气的老年患者在重症监护病房(ICU)之外接受治疗。这些患者是否应在 ICU 接受治疗的决策没有明确的指导方针。因此,我们进行了一项研究,旨在确定该人群的分诊标准和与院内死亡率相关的因素。

方法

本前瞻性、非干预性、观察性研究纳入了医院内所有接受机械通气的老年(≥65 岁)内科患者。

结果

在 579 次通气中,283 次(48.9%)在 ICU 进行,296 次(51.1%)在非 ICU 病房进行。65-74 岁、75-84 岁和 85 岁以上年龄组 ICU 通气的百分比分别为 62%、45%和 23%。在 ICU 进行通气的决策显著且独立地受年龄(优势比(OR)=0.945,P<0.001)和入院前功能状态(功能独立性测量(FIM)量表)(OR=1.054,P<0.001)的影响。与非 ICU 病房(68.2%)相比,ICU 中的院内死亡率为 53.0%(P<0.001),但 ICU 住院本身并未独立且显著地影响死亡率。

结论

在以色列,大多数老年患者在 ICU 之外接受通气治疗,并且 ICU 通气的比例随着年龄的增长而降低。在我们的研究组中,ICU 中接受通气的老年患者死亡率较低与患者特征有关,而与 ICU 治疗本身无关。尽管这项研究的实施环境在当今西方世界并不常见,但研究结果指出了可能的管理方法,以应对未来老年患者对机械通气的需求超过重症监护床位供应的情况。此外,本研究的结果有助于寻找在不对接受通气的老年患者的结果产生负面影响的情况下降低成本的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5852/2887160/219f6f6ac761/cc8935-1.jpg

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