Bernstein I L, Taylor E M, Bentson K L
Department of Psychology, University of Washington, Seattle 98195.
Am J Physiol. 1991 May;260(5 Pt 2):R906-10. doi: 10.1152/ajpregu.1991.260.5.R906.
Tumor necrosis factor (TNF) or cachectin has been proposed as an important mediator of cancer anorexia and cachexia. The present studies examined the extent to which TNF administration generates symptoms similar to those produced by tumor growth. Like the growth of certain tumors, TNF administration was found to be associated with the development of strong aversions to a novel diet. Area postrema lesions were found to significantly attenuate the effects of TNF on intake of a novel diet, a finding previously reported for tumor anorexia. In addition, the anorexic effects of TNF differed considerably as a function of the novelty of the diet. When the available diet was novel, effects of TNF in lowering food intake were substantial, whereas more modest effects were seen when the diet was familiar. These findings provide evidence for parallels between TNF- and tumor-induced anorexias. Nonetheless, these studies also confirm previous observations of the rapid development of tolerance to the anorexic effects of TNF, a finding that is not consistent with a role for TNF as a critical mediator of tumor anorexia.
肿瘤坏死因子（TNF）或恶病质素被认为是癌症厌食和恶病质的重要介质。本研究考察了给予TNF产生与肿瘤生长所产生症状相似症状的程度。与某些肿瘤的生长一样，发现给予TNF与对新饮食产生强烈厌恶有关。发现最后区损伤可显著减弱TNF对新饮食摄入的影响，这一发现先前已有关于肿瘤性厌食症的报道。此外，TNF的厌食作用因饮食的新颖性而有很大差异。当可获得的饮食是新的时，TNF降低食物摄入量的作用很大，而当饮食是熟悉的时，作用则较小。这些发现为TNF诱导的厌食症和肿瘤诱导的厌食症之间的相似性提供了证据。尽管如此，这些研究也证实了先前关于对TNF厌食作用快速产生耐受性的观察结果，这一发现与TNF作为肿瘤性厌食症关键介质的作用不一致。
