Aharonson-Raz Karin, Singh Baljit
Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan.
Can J Vet Res. 2010 Jan;74(1):45-9.
Endotoxemia causes significant mortality and morbidity in horses. The mechanisms underlying this complex pathophysiology remain unclear. Therefore, effective tools to treat endotoxemia in horses are lacking. Furthermore, the multifactorial and multiorgan pathophysiology of equine endotoxemia has not been fully addressed, especially the lung injury associated with endotoxemia. Within the context of the broader picture of endotoxemia and lung injury, we offer a perspective on the roles of pulmonary intravascular macrophages in endotoxin-induced lung inflammation in horses.
内毒素血症在马匹中会导致显著的死亡率和发病率。这种复杂病理生理学背后的机制仍不清楚。因此，缺乏治疗马匹内毒素血症的有效工具。此外，马属动物内毒素血症的多因素和多器官病理生理学尚未得到充分研究，尤其是与内毒素血症相关的肺损伤。在更广泛的内毒素血症和肺损伤背景下，我们就肺血管内巨噬细胞在马匹内毒素诱导的肺部炎症中的作用提供一种观点。
