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自体骨软骨马赛克移植术在运动员人群中的临床应用:一项长达 17 年的前瞻性多中心研究。

Clinical experiences with autologous osteochondral mosaicplasty in an athletic population: a 17-year prospective multicenter study.

机构信息

Uzsoki Hospital, Department of Orthopaedics, Mexikói strasse 62, Budapest, Hungary.

出版信息

Am J Sports Med. 2010 Jun;38(6):1125-33. doi: 10.1177/0363546509360405. Epub 2010 Apr 1.

Abstract

BACKGROUND

Several methods are used to treat focal chondral and osteochondral defects on the weightbearing surfaces of synovial joints. Autologous osteochondral grafting is 1 option used to replace hyaline cartilage in the defect.

HYPOTHESIS

Mosaicplasty is effective in returning elite athletes to participation in sports.

STUDY DESIGN

Case series; Level of evidence, 4.

METHODS

In 3 institutes, 354 of 383 patients were followed from 2 to 17 years (average, 9.6 years). The results of mosaicplasty were prospectively evaluated at 6 weeks, 3 months, 6 months, and yearly with patient-reported outcomes measures and radiographs.

RESULTS

Slight or moderate degenerative changes (Fairbank grade I or II) were detected preoperatively in 27% of the cases and in 36% of the cases at follow-up. Fairbank grade III changes were observed in 5 cases. An average radiographic deterioration of 0.32 on the Fairbank scale was detected (preoperative, 0.34; postoperative, 0.66). Good to excellent results were found in 91% of femoral mosaicplasties, 86% of tibial, and 74% of patellofemoral; 92% of talar mosaicplasties had similar results (Hannover ankle scoring system). Patellofemoral pain related to graft harvest was observed in 5% of cases. Second-look arthroscopies revealed good, congruent, gliding surfaces of the transplants and acceptable fibrocartilage coverage of donor sites in 16 patients and degenerative changes of the transplants in 5 cases. Histological evaluation revealed good graft incorporation in all 11 cases. Two infections and 3 deep venous thromboses occurred.

CONCLUSION

Despite a higher rate of preoperative osteoarthritic changes in the athletic patients, clinical outcomes of mosaicplasty in this group demonstrated a success rate similar to that of less athletic patients. Higher motivation resulted in better subjective evaluation. Slight deterioration in results occurred during the 9.6-year follow-up; thus, autologous osteochondral mosaicplasty may be a useful alternative for the treatment of 1.0- to 4.0-cm(2) focal chondral and osteochondral lesions in competitive athletes.

摘要

背景

有几种方法可用于治疗滑膜关节负重面的局灶性软骨和软骨下骨缺损。自体软骨骨软骨移植是修复软骨缺损的一种选择。

假设

马赛克plasty 可有效使精英运动员重返运动。

研究设计

病例系列;证据水平,4 级。

方法

在 3 家机构中,383 例患者中有 354 例(平均 9.6 年)接受了随访。在 6 周、3 个月、6 个月和每年,通过患者报告的结果测量和影像学检查对马赛克plasty 的结果进行前瞻性评估。

结果

27%的病例术前和 36%的病例随访时存在轻微或中度退行性改变(Fairbank 分级 I 或 II)。5 例出现 Fairbank 分级 III 改变。Fairbank 分级平均恶化 0.32(术前 0.34;术后 0.66)。股骨马赛克plasty 的优良率为 91%,胫骨为 86%,髌股关节为 74%;距骨马赛克plasty 的结果相似(汉诺威踝关节评分系统),为 92%。5%的病例出现与移植物采集相关的髌股关节疼痛。16 例患者的关节镜检查显示移植物表面良好、一致、滑动,供体部位纤维软骨覆盖可接受,5 例患者的移植物出现退行性改变。组织学评估显示所有 11 例移植物均有良好的整合。发生 2 例感染和 3 例深静脉血栓形成。

结论

尽管运动患者术前骨关节炎改变的发生率较高,但该组患者的马赛克plasty 临床结果显示成功率与运动较少的患者相似。较高的动机导致更好的主观评估。在 9.6 年的随访中,结果出现轻微恶化;因此,自体软骨马赛克plasty 可能是治疗 1.0-4.0cm² 局灶性软骨和软骨下骨病变的一种有用的选择。

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