Department of Community Medicine, Ehime University Graduate School of Medicine, Tōon, Ehime, 791-0295, Japan.
Department of Internal Medicine, Seiyo Municipal Nomura Hospital, 9-53 Nomura, Nomura-cho, Seiyo, Ehime, 797-1212, Japan.
J Endocrinol Invest. 2018 Apr;41(4):421-429. doi: 10.1007/s40618-017-0760-5. Epub 2017 Sep 25.
Higher glycated hemoglobin (Hb) (HbA1c) is significantly associated with an increased risk of cardiovascular disease (CVD). Serum uric acid (SUA) levels are associated with glucose intolerance and type 2 diabetes. Whether gender-specific differences regarding the relationship between SUA levels and HbA1c exist is unknown.
We recruited 1636 (men, 696 aged of 70 ± 10 years; women, 940 aged of 70 ± 9 years) participants and enrolled in the study during their annual health examination from a single community. We investigated the association between SUA levels and HbA1c within each gender.
Multiple linear regression analysis showed that in men, SUA (β = -0.091, p = 0.014) with prevalence of antidiabetic medication (β = 0.428, p < 0.001) and eGFR (β = 0.112, p = 0.016) were significantly and negatively associated with HbA1c, and in women, SUA (β = 0.101, p = 0.002) with prevalence of antidiabetic medication (β = 0.458, p < 0.001) were significantly and positively associated with HbA1c. Moreover, the interaction between gender and SUA (β = 0.445, p < 0.001) as well as gender (β = -0.465, p < 0.001), prevalence of antidiabetic medication (β = 0.444, p < 0.001), eGFR (β = 0.074, p = 0.014), and SUA (β = -0.356, p < 0.001) was a significant and independent determinant of HbA1c. A significant interactive effect of gender and SUA on determinants of HbA1c was noted in patients not on antidiabetic medications, regardless of age, HbA1c, and renal function.
The interaction between gender and SUA was associated with HbA1c independent of other metabolic factors in community-dwelling persons.
糖化血红蛋白（HbA1c）升高与心血管疾病（CVD）风险增加显著相关。血清尿酸（SUA）水平与葡萄糖耐量受损和 2 型糖尿病有关。SUA 水平与 HbA1c 之间的关系是否存在性别特异性差异尚不清楚。
我们招募了 1636 名参与者（男性 696 名，年龄 70±10 岁；女性 940 名，年龄 70±9 岁），并在他们参加年度健康检查时纳入了这项研究。我们在每个性别中研究了 SUA 水平与 HbA1c 之间的关系。
多元线性回归分析显示，在男性中，SUA（β=-0.091，p=0.014）与降糖药物的使用率（β=0.428，p<0.001）和 eGFR（β=0.112，p=0.016）呈显著负相关，而在女性中，SUA（β=0.101，p=0.002）与降糖药物的使用率（β=0.458，p<0.001）呈显著正相关。此外，性别与 SUA（β=0.445，p<0.001）以及性别（β=-0.465，p<0.001）、降糖药物的使用率（β=0.444，p<0.001）、eGFR（β=0.074，p=0.014）和 SUA（β=-0.356，p<0.001）之间的交互作用是 HbA1c 的显著独立决定因素。无论年龄、HbA1c 和肾功能如何，在未使用降糖药物的患者中，性别和 SUA 对 HbA1c 决定因素的交互作用均具有显著意义。
在社区居住的人群中，SUA 与 HbA1c 之间的相互作用与其他代谢因素无关。
