Vutyavanich Teraporn, Piromlertamorn Waraporn, Ellis Jason
Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Case Rep Med. 2010;2010:367505. doi: 10.1155/2010/367505. Epub 2010 Mar 30.
Empty follicle syndrome (EFS) is a condition in which no oocytes are obtained after an apparently successful ovarian stimulation. Genuine EFS (GEFS) is differentiated from false EFS by an optimal level of human chorionic gonadotropin on the day of oocyte retrieval. Some believe that GEFS does not exist and that it is only a reflection of the margin of error attendant upon the procedure of oocyte aspiration. Others believe that GEFS is caused by dysfunctional folliculogenesis, resulting in early atresia of oocytes. In this report, we present a case of apparent GEFS, in which immature oocytes were identified after filtration of follicular aspirates. Our findings suggest that delayed maturation of oocyte cumulus complexes in response to HCG might be an etiologic mechanism in some cases of GEFS. This creates a situation similar to the aspiration of immature follicles, where germinal vesicle-stage oocytes with dense scanty cumulus cells are often difficult to identify under a dissecting microscope.
空卵泡综合征（EFS）是一种在卵巢刺激看似成功后却未获得卵母细胞的病症。真性空卵泡综合征（GEFS）与假性EFS的区别在于取卵当天人绒毛膜促性腺激素处于最佳水平。一些人认为不存在GEFS，它只是卵母细胞抽吸过程中误差范围的一种反映。另一些人则认为GEFS是由卵泡发生功能障碍导致卵母细胞早期闭锁引起的。在本报告中，我们呈现了一例疑似GEFS的病例，其中在对卵泡抽吸物进行过滤后发现了未成熟卵母细胞。我们的研究结果表明，卵丘 - 卵母细胞复合体对人绒毛膜促性腺激素反应的成熟延迟可能是某些GEFS病例的病因机制。这就造成了一种类似于抽吸未成熟卵泡的情况，即带有稀疏卵丘细胞的生发泡期卵母细胞在解剖显微镜下通常难以识别。
