非甾体抗炎药与胰腺癌风险：一项巢式病例对照研究。
Non-steroidal anti-inflammatory drugs and pancreatic cancer risk: a nested case-control study.
机构信息
Cancer Epidemiology and Prevention Research Group, Centre for Public Health, Queen's University, Mulhouse Building, Royal Victoria Hospital, Belfast BT12 6BJ, Northern Ireland, UK.
出版信息
Br J Cancer. 2010 Apr 27;102(9):1415-21. doi: 10.1038/sj.bjc.6605636. Epub 2010 Apr 6.
BACKGROUND
Non-steroidal anti-inflammatory drug (NSAID) use has been linked with pancreatic cancer risk; however, findings from epidemiological studies are inconsistent.
METHODS
A nested case-control study was conducted within the UK General Practice Research Database. Cases (n=1141) had a diagnosis of primary cancer of the exocrine pancreas between January 1995 and June 2006. Controls (n=7954) were matched with each case on general practice site, sex and year of birth. Conditional logistic regression analyses were used to generate odds ratios (OR) and 95% confidence intervals (CI) associated with NSAID use compared with non-use.
RESULTS
Any use of NSAID in the 5 years before the index date or since entry into the database (excluding the year before diagnosis) was not associated with risk of pancreatic cancer; OR 0.96 (95% CI, 0.84-1.10) and 1.03 (95% CI 0.89-1.19), respectively. Exposure to NSAIDs for > 773 days, in the 5 years pre-diagnosis, was associated with a reduced risk of pancreatic cancer OR 0.78 (95%CI 0.62-0.97). There was evidence of reduced pancreatic cancer risk with long-term use (5 years or more) of lower doses of NSAIDs OR 0.70 (95% CI 0.49-0.99).
CONCLUSION
Long-term exposure to NSAIDs may be associated with a reduction in risk of pancreatic cancer.
背景
非甾体抗炎药（NSAID）的使用与胰腺癌风险相关；然而，来自流行病学研究的结果并不一致。
方法
在英国普通实践研究数据库中进行了一项嵌套病例对照研究。病例（n=1141）在 1995 年 1 月至 2006 年 6 月期间被诊断为外分泌胰腺原发性癌症。对照（n=7954）与每个病例在普通诊所、性别和出生年份上进行匹配。使用条件逻辑回归分析生成与 NSAID 使用相关的比值比（OR）和 95%置信区间（CI），与非使用相比。
结果
在指数日期之前或自进入数据库以来（不包括诊断前一年）的任何 NSAID 使用与胰腺癌风险无关；OR 分别为 0.96（95%CI，0.84-1.10）和 1.03（95%CI 0.89-1.19）。在诊断前 5 年内，暴露于 NSAIDs > 773 天与胰腺癌风险降低相关，OR 为 0.78（95%CI 0.62-0.97）。长期使用（5 年或更长时间）低剂量 NSAIDs 与胰腺癌风险降低有关，OR 为 0.70（95%CI 0.49-0.99）。
结论
长期接触 NSAIDs 可能与降低胰腺癌风险有关。
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