脂肪源干细胞：回顾与展望。
The adipose-derived stem cell: looking back and looking ahead.
机构信息
Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
出版信息
Mol Biol Cell. 2010 Jun 1;21(11):1783-7. doi: 10.1091/mbc.e09-07-0589. Epub 2010 Apr 7.
Abstract
In 2002, researchers at UCLA published a manuscript in Molecular Biology of the Cell describing a novel adult stem cell population isolated from adipose tissue-the adipose-derived stem cell (ASC). Since that time, the ASC has gone on to be one of the most popular adult stem cell populations currently being used in the stem cell field. With multilineage mesodermal potential and possible ectodermal and endodermal potentials also, the ASC could conceivably be an alternate to pluripotent ES cells in both the lab and in the clinic. In this retrospective article, a historical perspective on the ASC is given together with exciting new applications for the stem cell being considered today.
摘要
2002 年，加州大学洛杉矶分校的研究人员在《细胞分子生物学》杂志上发表了一篇论文，描述了一种从脂肪组织中分离出来的新型成体干细胞群体——脂肪来源的干细胞（ASC）。从那时起，ASC 一直是目前干细胞领域中使用最广泛的成体干细胞群体之一。由于具有多能中胚层潜能，以及可能的外胚层和内胚层潜能，ASC 可以作为多能胚胎干细胞的替代品，无论是在实验室还是在临床中。在这篇回顾性文章中，我们从历史的角度介绍了 ASC，同时还探讨了当今正在考虑的干细胞的一些令人兴奋的新应用。
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