利用 spoligotyping 追溯美国人类结核分枝杆菌（Mycobacterium bovis tuberculosis）的起源来自墨西哥的牛。
Tracing the origins of Mycobacterium bovis tuberculosis in humans in the USA to cattle in Mexico using spoligotyping.
机构信息
Division of Global Public Health, University of California-San Diego, Institute of the Americas, 10111 N. Torrey Pines Rd., La Jolla, CA 92093-0507, USA.
出版信息
Int J Infect Dis. 2010 Sep;14 Suppl 3:e129-35. doi: 10.1016/j.ijid.2009.11.037. Epub 2010 Apr 18.
OBJECTIVES
To compare genotypes of Mycobacterium bovis strains from humans in Southern California with genotypes of M. bovis strains in cattle in Mexico and the USA to explore the possible origins of human infections.
METHODS
We conducted a descriptive analysis of M. bovis genotypes from a binational population of humans and cattle using spacer oligonucleotide typing (spoligotyping).
RESULTS
One hundred six human M. bovis spoligotypes were compared to spoligotypes from 496 Mexican cattle and 219 US cattle. Twelve spoligotype patterns were identified among human cases and 126 spoligotype patterns were detected in cattle. Over 91% (97/106) of the human M. bovis isolates had spoligotypes that were identical to those found in Mexican cattle. Four human cases had spoligotypes that matched both cattle born in Mexico and in the USA. Nine human cases had spoligotypes that did not match cattle born in Mexico or the USA.
CONCLUSIONS
Our data indicate that the population of M. bovis strains causing human TB disease in Southern California is closely related to the M. bovis strain population found in Mexican cattle and supports existing epidemiological evidence that human M. bovis disease in San Diego likely originated from Mexican cattle.
目的
比较加利福尼亚南部人类感染的牛分枝杆菌菌株与墨西哥和美国牛分枝杆菌菌株的基因型，以探讨人类感染的可能来源。
方法
我们使用间隔寡核苷酸分型（ spoligotyping ）对来自人类和牛的跨国人群的牛分枝杆菌基因型进行了描述性分析。
结果
将 106 个人类分枝杆菌 spoligotypes 与 496 头墨西哥牛和 219 头美国牛的 spoligotypes 进行了比较。在人类病例中发现了 12 种 spoligotype 模式，在牛中发现了 126 种 spoligotype 模式。超过 91%（97/106）的人类分枝杆菌分离株的 spoligotype 与在墨西哥牛中发现的 spoligotype 相同。有 4 例人类病例的 spoligotype 与在墨西哥和美国出生的牛相匹配。有 9 例人类病例的 spoligotype 与在墨西哥或美国出生的牛不匹配。
结论
我们的数据表明，导致加利福尼亚南部人类结核病的牛分枝杆菌菌株的种群与在墨西哥牛中发现的牛分枝杆菌菌株种群密切相关，并支持现有的流行病学证据，即圣地亚哥的人类牛分枝杆菌病可能起源于墨西哥牛。
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