Sunder S, Lanotte P, Godreuil S, Martin C, Boschiroli M L, Besnier J M
CHRU de Tours, Service de Médecine Interne et Maladies Infectieuses, Tours, France.
J Clin Microbiol. 2009 Apr;47(4):1249-51. doi: 10.1128/JCM.02042-08. Epub 2009 Jan 26.
Human-to-human transmission of Mycobacterium bovis in two immunocompetent patients from the same family was confirmed by spoligotyping (pattern F35, which was only observed in cattle from the same area in France). A single allelic difference between animal and human isolates was observed with mycobacterial interspersed repetitive units containing variable-number tandem repeats, suggesting a jump across the species barrier.
通过间隔寡核苷酸分型(F35型,仅在法国同一地区的牛中观察到)证实了两例来自同一家族的免疫功能正常患者之间存在牛分枝杆菌的人际传播。在含有可变数目串联重复序列的分枝杆菌散布重复单元中,观察到动物和人类分离株之间存在单个等位基因差异,这表明存在跨物种屏障的跳跃传播。