从中华鼯鼠粪便中分离得到的二萜类化合物。

Diterpenoids from the feces of Trogopterus xanthipes.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.

出版信息

J Nat Prod. 2010 May 28;73(5):865-9. doi: 10.1021/np900814s.

DOI:10.1021/np900814s

PMID:20402524

Abstract

Three new isopimarane diterpenoids, trogopteroids A-C (1-3), four new aromatic diterpenoids, trogopteroids D-G (4-7), and 12 known diterpenoids were isolated from the feces of Trogopterus xanthipes. Their structures were identified using spectroscopic methods. The relative configuration of 1 was confirmed by quantum calculations. Compound 1 represents the first example of a norisopimarane diterpenoid with an 8alpha,15alpha-olide ring. With the exception of compound 14, all diterpenoids were evaluated for cytotoxicity against seven human tumor cell lines.

摘要

从中华鼯鼠（Trogopterus xanthipes）的粪便中分离得到三个新的松脂烷二萜类化合物，即 trogopteroids A-C（1-3），四个新的芳香二萜类化合物，即 trogopteroids D-G（4-7），以及 12 个已知的二萜类化合物。利用光谱学方法鉴定了它们的结构。通过量子计算确定了 1 的相对构型。化合物 1 代表了第一个具有 8alpha,15alpha-内酯环的降松脂烷二萜类化合物。除了化合物 14 之外，所有的二萜类化合物都对七种人肿瘤细胞系进行了细胞毒性评估。