The Brooklyn Hospital Center, 121 DeKalb Avenue, Brooklyn, NY 11201, United States.
Med Hypotheses. 2010 Oct;75(4):378-82. doi: 10.1016/j.mehy.2010.04.001. Epub 2010 Apr 18.
A whole host of epidemiological studies have reported lower cancer rates and mortality in high-altitude regions. These studies are reviewed and discussed in detail. Evidence for the salutary role of vitamin D in protecting against cancer and other maladies will also be reviewed and discussed. The dependence of vitamin D production on sunlight and its enhancement with altitude will be demonstrated. The hypothesis is advanced and developed that the lower cancer rates observed at high altitudes arise from enhanced sunlight-induced vitamin D production levels. Protective vitamin D mechanisms which support this hypothesis as well as other supportive medical evidence are also presented.
大量的流行病学研究报告表明，高海拔地区的癌症发病率和死亡率较低。本文详细回顾和讨论了这些研究。还回顾和讨论了维生素 D 对预防癌症和其他疾病的有益作用的证据。将证明维生素 D 产生对阳光的依赖性及其随海拔的增强。提出并发展了这样一种假设，即高海拔地区观察到的较低癌症发病率是由于阳光诱导的维生素 D 产生水平增强所致。支持这一假设的保护性维生素 D 机制以及其他支持性医学证据也将被提出。
