从三叶崖爬藤中分离得到三个新的吲哚生物碱。
Three new indole alkaloids from Trigonostemon lii.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PRC.
出版信息
Org Lett. 2010 May 21;12(10):2370-3. doi: 10.1021/ol100715x.
PMID:20405956
Abstract
Three unprecedented indole alkaloids, trigonoliimines A-C (1-3) with a unique polycyclic system, were isolated from the leaves of Trigonostemon lii Y. T. Chang. The structures of 1-3 were determined by the spectroscopic, computational, and CD exciton chirality approaches. Trigonoliimine A showed modest anti-HIV-1 activity (EC(50) = 0.95 microg/mL, TI = 7.9).
摘要
从三叶苦 Lii Y. T. Chang 的叶子中分离得到了三种前所未有的吲哚生物碱，三角龙胺 A-C（1-3），具有独特的多环系统。通过光谱、计算和 CD 外消旋手性方法确定了 1-3 的结构。三角龙胺 A 表现出适度的抗 HIV-1 活性（EC（50）= 0.95μg/mL，TI = 7.9）。
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