白花丹叶对雌性白化大鼠的抗排卵和雌激素活性。
Antiovulatory and estrogenic activity of Plumbago rosea leaves in female albino rats.
机构信息
Department of Pharmacognosy, B. R. Nahata College of Pharmacy and Research Center, Mhow Neemuch Road, Mandsaur - 458 001, Madhya Pradesh, India.
出版信息
Indian J Pharmacol. 2009 Dec;41(6):273-7. doi: 10.4103/0253-7613.59927.
OBJECTIVE
To evaluate the effect of petroleum ether (60-80 degrees ), chloroform, acetone, ethanol and aqueous extracts of Plumbago rosea leaves on the estrous cycle and to identify the estrogenic activity of active acetone and ethanol extracts in female albino rats.
METHODS
PLANT EXTRACTS WERE TESTED FOR THEIR EFFECT ON THE ESTROUS CYCLE AT TWO DOSE LEVELS: 200 and 400 mg/kg, respectively. The effective acetone and ethanol extracts were further studied on estrogenic activity in rats. Histological studies of the uterus were carried out to confirm their estrogenic activity.
RESULTS
The acetone and ethanol extracts were most effective in interrupting the normal estrous cycle of the rats (P<0.05, <0.01, <0.001). These later exhibited prolonged diestrous stage of the estrous cycle with consequent temporary inhibition of ovulation. The antiovulatory activity was reversible on discontinuation of treatment. Both the extracts showed significant estrogenic and antiestrogenic activity.
CONCLUSION
The acetone and ethanolic extracts of P. rosea leaves have an antifertility activity.
目的
评估石油醚（60-80 度）、氯仿、丙酮、乙醇和白花丹叶的水提物对动情周期的影响，并鉴定活性丙酮和乙醇提取物在雌性白化大鼠中的雌激素活性。
方法
在两个剂量水平（分别为 200 和 400mg/kg）下测试植物提取物对动情周期的影响。进一步研究有效丙酮和乙醇提取物在大鼠中的雌激素活性。对子宫进行组织学研究以确认其雌激素活性。
结果
丙酮和乙醇提取物最有效地中断了大鼠的正常动情周期（P<0.05，<0.01，<0.001）。这些提取物随后表现出发情周期的延长发情期，随后暂时抑制排卵。停药后，抗排卵活性是可逆的。两种提取物均显示出显著的雌激素和抗雌激素活性。
结论
白花丹叶的丙酮和乙醇提取物具有抗生育活性。
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