Department of Pediatric Dentistry, Pacific Dental College & Hospital, Udaipur, Rajasthan, India.
Int J Paediatr Dent. 2010 May;20(3):186-92. doi: 10.1111/j.1365-263X.2010.01032.x.
Lead toxicity particularly affects children because of their increased capacity for absorption and retention. Blood-lead (BPb) levels reflect recent exposure and are of limited value in predicting neurotoxicity, whereas in teeth, lead accumulates over a long period of time and provides an integrated record of lead exposure from intrauterine life until the teeth are shed.
The present study aimed to relate tooth-lead (TPb) and BPb levels in children residing near a zinc-lead smelter in India, and to evaluate the effectiveness of primary teeth as bioindicators of life-long lead exposure.
The lead levels in primary teeth and blood of 100 children aged between 5 and 13 years, living in the proximity of a zinc-lead smelter were measured by atomic absorption spectrophotometry. The mean levels were tabulated based on village, age, sex and tooth type, and analysed statistically.
The mean BPb level was significantly influenced by proximity to the lead source, but not by age or sex. There was no consistent pattern of correlation between BPb and TPb levels.
Primary teeth showed significantly high lead levels compared to blood; they reflect cumulative exposure to lead and prove to be better indicators of body lead burden.
由于儿童吸收和保留铅的能力增强，铅毒性对儿童的影响尤其大。血铅（BPb）水平反映了近期的暴露情况，对预测神经毒性的价值有限，而在牙齿中，铅会在很长一段时间内积累，并提供从宫内生活到牙齿脱落期间铅暴露的综合记录。
本研究旨在研究印度一家锌铅冶炼厂附近儿童的牙齿铅（TPb）和 BPb 水平，并评估乳牙作为终生铅暴露生物标志物的有效性。
采用原子吸收分光光度法测量了 100 名 5 至 13 岁居住在锌铅冶炼厂附近的儿童的乳牙和血液中的铅含量。根据村庄、年龄、性别和牙齿类型对平均值进行制表，并进行统计学分析。
BPb 水平与铅源的接近程度显著相关，但与年龄或性别无关。BPb 和 TPb 水平之间没有一致的相关模式。
与血液相比，乳牙的铅含量明显较高；它们反映了铅的累积暴露情况，是更好的体内铅负荷指标。
