Department of Neurosurgery, Treviso Regional Hospital Ca'Foncello, University of Padova, Pzza. le Ospedale Civile No. 1, Treviso, Italy.
J Clin Neurosci. 2010 Jul;17(7):905-7. doi: 10.1016/j.jocn.2009.11.010. Epub 2010 Apr 20.
Aquaporin 1 (AQP1) is a molecular water channel expressed in many anatomical locations, particularly in epithelial barriers specialized in water transport. The aim of this study was to investigate AQP1 expression in chronic subdural hematoma (CSDH) membranes. In this preliminary study, 11 patients with CSDH underwent burr hole craniectomy and drainage. Membrane specimens were stained with a monoclonal antibody targeting AQP1 for immunohistochemical analysis. The endothelial cells of the sinusoid capillaries of the outer membranes exhibited an elevated immunoreactivity to AQP1 antibody compared to the staining intensity of specimens from the inner membrane and normal dura. These findings suggest that the outer membrane might be the source of the increased fluid accumulation responsible for chronic hematoma enlargement.
水通道蛋白 1（AQP1）是一种在许多解剖部位表达的分子水通道，特别是在专门从事水运输的上皮屏障中。本研究旨在研究慢性硬脑膜下血肿（CSDH）膜中 AQP1 的表达。在这项初步研究中，11 例 CSDH 患者接受颅骨钻孔和引流术。使用针对 AQP1 的单克隆抗体对膜标本进行免疫组织化学分析。与内膜和正常硬脑膜标本的染色强度相比，外膜窦毛细血管的内皮细胞对 AQP1 抗体的免疫反应性升高。这些发现表明，外膜可能是导致慢性血肿增大的液体蓄积增加的来源。
