Department of Biology, Laboratory of Freshwater & Stress Ecology, Humboldt-Universität zu Berlin, Spaethstr. 80/81, 12437 Berlin, Germany.
J Gerontol A Biol Sci Med Sci. 2010 Jun;65(6):626-35. doi: 10.1093/gerona/glq051. Epub 2010 Apr 22.
This study shows that exposure to low concentrations of the polyphenol tannic acid (TA) induces potent life-prolonging properties in Caenorhabditis elegans. In addition, enhanced thermal stress resistance, reduced growth, and slightly increased oxidative stress resistance were observed, although reproductive capacities and pharyngeal pumping rate were not modulated. Exploiting a suite of 14 mutant strains revealed that the mitogen-activated protein kinase kinase SEK-1 (SAPK/ERK kinase) is a key player involved in TA-mediated longevity. It is conceivable that TA mimics pathogen action and therefore activates the SEK-1-mediated pathogen resistance pathway. This pathway is thought to inhibit potential detrimental effects of TA and may also be involved in the longevity process. The observed dose response suggests the presence of a hormesis effect, and the growth impairment is in agreement with the "Disposable Soma Theory." This report underlines the uniqueness of TA-mediated longevity and facilitates a first glimpse into its complex mode of action.
这项研究表明，暴露于低浓度的多酚单宁酸（TA）会诱导秀丽隐杆线虫产生强大的延长寿命特性。此外，观察到增强的热应激抗性、生长减缓以及略微增强的氧化应激抗性，尽管生殖能力和咽部抽吸率没有调节。利用一套 14 种突变株揭示了丝裂原激活的蛋白激酶激酶 SEK-1（SAPK/ERK 激酶）是参与 TA 介导的长寿的关键参与者。可以想象，TA 模拟病原体的作用，因此激活了 SEK-1 介导的病原体抗性途径。该途径被认为抑制 TA 的潜在有害影响，并且可能也参与长寿过程。观察到的剂量反应表明存在兴奋效应，而生长受损与“可抛弃体细胞理论”一致。本报告强调了 TA 介导的长寿的独特性，并为其复杂的作用模式提供了初步的了解。
