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（S）-9-（3,4-二羟基丁基）腺嘌呤的掺入对寡脱氧核苷酸酶稳定性和碱基配对性质的影响。

Influence of the incorporation of (S)-9-(3,4-dihydroxybutyl)adenine on the enzymatic stability and base-pairing properties of oligodeoxynucleotides.

作者信息

Augustyns K, Van Aerschot A, Van Schepdael A, Urbanke C, Herdewijn P

机构信息

Rega Institute for Medical Research, Leuven, Belgium.

出版信息

Nucleic Acids Res. 1991 May 25;19(10):2587-93. doi: 10.1093/nar/19.10.2587.

DOI:10.1093/nar/19.10.2587
PMID:2041735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC328174/
Abstract

(S)-9-(3,4-dihydroxybutyl)adenine was used at several positions as nucleoside substitute in the synthesis of dimers and 13-mers. Therefore we used the phosporamidite and the H-phosphonate chemistry. The nuclease susceptibilities and the base-pairing properties of these oligomers have been evaluated.

摘要

（S）-9-（3,4-二羟基丁基）腺嘌呤在多个位置用作核苷替代物，用于合成二聚体和13聚体。因此，我们采用了亚磷酰胺和H-膦酸酯化学方法。对这些寡聚物的核酸酶敏感性和碱基配对特性进行了评估。

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本文引用的文献

1
Structure and synthesis of dihydroxypentyluracil from bacteriophage SP-15 deoxyribonucleic acid.来自噬菌体SP-15脱氧核糖核酸的二羟基戊基尿嘧啶的结构与合成
J Am Chem Soc. 1973 Dec 26;95(26):8749-57. doi: 10.1021/ja00807a041.
2
Synthesis of DNA via deoxynucleoside H-phosphonate intermediates.通过脱氧核苷H-膦酸酯中间体合成DNA。
Nucleic Acids Res. 1986 Jul 11;14(13):5399-407. doi: 10.1093/nar/14.13.5399.
3
Derivatization of controlled pore glass beads for solid phase oligonucleotide synthesis.用于固相寡核苷酸合成的可控孔径玻璃珠的衍生化
Biotechniques. 1988 Sep;6(8):768-75.
4
Physicochemical properties of phosphorothioate oligodeoxynucleotides.硫代磷酸酯寡脱氧核苷酸的物理化学性质。
Nucleic Acids Res. 1988 Apr 25;16(8):3209-21. doi: 10.1093/nar/16.8.3209.
5
Selective hydrolysis by exo- and endonucleases of phosphodiester bonds adjacent to an apurinic site.外切核酸酶和内切核酸酶对与脱嘌呤位点相邻的磷酸二酯键进行选择性水解。
Nucleic Acids Res. 1989 May 25;17(10):3735-45. doi: 10.1093/nar/17.10.3735.