Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
BMC Endocr Disord. 2011 Oct 11;11:16. doi: 10.1186/1472-6823-11-16.
We examined the association of biomarkers of inflammation and endothelial dysfunction with diabetes and metabolic syndrome (MetS) in persons from Inner Mongolia.
A cross-sectional study was conducted among 2,536 people aged 20 years and older from Inner Mongolia, China. Overnight fasting blood samples were obtained to measure plasma concentrations of high sensitivity C-reactive protein (hsCRP), soluble inter-cellular adhesion molecule-1 (sICAM-1), sE-selectin, angiotensin II, high density lipoprotein cholesterol, triglycerides, and blood glucose. Waist circumference and blood pressure were measured by trained staff. MetS was defined according to the modified ATP III definition for Asians. Elevated level of the biomarker was defined as values in the upper tertile of the distribution. Participants were categorized into one of four groups based on the presence or absence of metabolic and glycemic abnormalities: 1) free of prediabetes, diabetes and MetS (reference group), 2) prediabetes or diabetes only, 3) MetS without prediabetes or diabetes, and 4) MetS plus prediabetes or diabetes. The multivariable models are adjusted for age, gender, smoking, drinking, family history of hypertension, and body mass index.
Among study participants, 18.5% had prediabetes, 3.6% had diabetes, and 27.4% of the entire study population had 3 or more components of the MetS. Elevated hsCRP was associated with an increased odds of prediabetes or diabetes only, MetS without prediabetes or diabetes, and MetS plus prediabetes or diabetes with multivariable adjusted odds ratios (95% confidence intervals) of 2.3 (1.7-3.1), 3.0 (2.4-3.8), and 5.8 (4.5-7.5), respectively. Elevated sICAM-1 was associated with increased odds (95% CI) of prediabetes or diabetes only (2.1, 1.6-2.9) and MetS plus prediabetes or diabetes (4.2, 3.2-5.3) but was not associated with MetS alone. Elevated sE-selectin was associated with a modestly increased risk of MetS (OR 1.7, 95% CI 1.4-2.2). Elevated levels of Angiotensin II were not associated with the MetS plus prediabetes or diabetes in this study.
Diabetes and the MetS are common in the Inner Mongolia population. The biomarkers of inflammation and endothelial dysfunction are associated with increased risk for diabetes and MetS in this population. These results are consistent with results from other populations.
我们研究了内蒙古人群中炎症和内皮功能障碍生物标志物与糖尿病和代谢综合征（MetS）的关系。
在中国内蒙古进行了一项横断面研究，纳入了 2536 名年龄在 20 岁及以上的人群。采集隔夜空腹血样，测量高敏 C 反应蛋白（hsCRP）、可溶性细胞间黏附分子-1（sICAM-1）、sE-选择素、血管紧张素 II、高密度脂蛋白胆固醇、甘油三酯和血糖浓度。由经过培训的工作人员测量腰围和血压。根据亚洲人改良 ATP III 定义，MetS 定义为代谢和血糖异常。将生物标志物升高定义为分布的上三分之一值。根据是否存在糖代谢和代谢异常，将参与者分为以下四组之一：1）无糖尿病前期、糖尿病和代谢综合征（参考组）；2）糖尿病前期或糖尿病；3）无糖尿病前期或糖尿病的代谢综合征；4）代谢综合征伴糖尿病前期或糖尿病。多变量模型调整了年龄、性别、吸烟、饮酒、高血压家族史和体重指数。
在研究参与者中，18.5%有糖尿病前期，3.6%有糖尿病，整个研究人群中有 27.4%有 3 个或更多的代谢综合征成分。hsCRP 升高与糖尿病前期或糖尿病、无糖尿病前期或糖尿病的代谢综合征以及代谢综合征伴糖尿病前期或糖尿病的发生风险增加有关，多变量调整后的比值比（95%置信区间）分别为 2.3（1.7-3.1）、3.0（2.4-3.8）和 5.8（4.5-7.5）。sICAM-1 升高与糖尿病前期或糖尿病（2.1，1.6-2.9）和代谢综合征伴糖尿病前期或糖尿病（4.2，3.2-5.3）的发生风险增加有关，但与单纯代谢综合征无关。sE-选择素升高与代谢综合征的风险适度增加相关（OR 1.7，95%CI 1.4-2.2）。在这项研究中，血管紧张素 II 水平升高与代谢综合征伴糖尿病前期或糖尿病无关。
糖尿病和代谢综合征在内蒙古人群中很常见。炎症和内皮功能障碍的生物标志物与该人群中糖尿病和代谢综合征的发生风险增加有关。这些结果与其他人群的结果一致。
