Department of Foods and Nutrition, Purdue University, 212 Stone Hall, 700 W State Street, West Lafayette, IN 47907-2059, USA.
J Am Coll Nutr. 2009 Oct;28(5):574-82. doi: 10.1080/07315724.2009.10719789.
Concord grape juice (CGJ) is a rich source of phenolic antioxidants, with a range of putative health benefits. However, high beverage energy and fructose intake may lead to weight gain and insulin resistance, respectively. This study assessed the effects of CGJ consumption for 12 weeks on appetite, diet, body weight, lipid profile, and antioxidant status.
Seventy-six men and women aged 18 to 50 years with a body mass index of 25.0 to 29.9 kg/m(2) consumed either 480 mL CGJ, 480 mL substitute (polyphenol-free) grape-flavored drink (SGD), or no beverage (NTG) daily for 12 weeks. Anthropometric indices were measured biweekly, dietary intake and appetite were assessed 4 times during the study, and plasma oxygen radical absorbance capacity, lipids, and oral glucose tolerance were assessed at baseline and week 12.
Compared to baseline, the SGD group reported a reduction in fullness (p < 0.005) and gained 1.6 kg (p < 0.05). No significant changes in body weight or composition were observed with CGJ or control (no beverage added to diet). Mean dietary compensation was 98.8% for SGD and 81.0% for CGJ. Serum glucose and insulin area under the curve (180 minutes) increased slightly, but this was significant only with CGJ. Plasma antioxidant capacity did not differ across groups, suggesting no effect of chronic CGJ ingestion on antioxidant status.
Daily consumption of CGJ for 12 weeks did not lead to significant weight gain, but consumption of SGD did. The basis of this differential response could not be documented, but it is hypothesized to be a result of dietary compensation and effects of CGJ polyphenols on thermogenesis and substrate oxidation.
康科德葡萄汁（CGJ）是酚类抗氧化剂的丰富来源，具有一系列潜在的健康益处。然而，高饮料能量和果糖摄入可能分别导致体重增加和胰岛素抵抗。本研究评估了 CGJ 消费 12 周对食欲、饮食、体重、血脂谱和抗氧化状态的影响。
76 名年龄在 18 至 50 岁之间、体重指数为 25.0 至 29.9 kg/m2 的男性和女性每天分别饮用 480 毫升 CGJ、480 毫升替代物（不含多酚）葡萄味饮料（SGD）或不饮用任何饮料（NTG），持续 12 周。每隔两周测量一次人体测量指数，在研究期间评估 4 次饮食摄入和食欲，基线和第 12 周评估血浆氧自由基吸收能力、脂质和口服葡萄糖耐量。
与基线相比，SGD 组饱腹感降低（p < 0.005），体重增加 1.6 公斤（p < 0.05）。CGJ 或对照组（饮食中未添加饮料）的体重或成分均无明显变化。SGD 的平均膳食补偿为 98.8%，CGJ 的平均膳食补偿为 81.0%。血清葡萄糖和胰岛素曲线下面积（180 分钟）略有增加，但仅 CGJ 组有统计学意义。各组血浆抗氧化能力无差异，提示慢性 CGJ 摄入对抗氧化状态无影响。
CGJ 每天消费 12 周不会导致体重显著增加，但 SGD 消费会导致体重增加。这种差异反应的基础无法确定，但据推测是由于膳食补偿和 CGJ 多酚对产热和底物氧化的影响所致。
