Esmaeelpour Marieh, Povazay Boris, Hermann Boris, Hofer Bernd, Kajic Vedran, Kapoor Ketan, Sheen Nik J L, North Rachel V, Drexler Wolfgang
School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK.
Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5260-6. doi: 10.1167/iovs.10-5196. Epub 2010 May 5.
To evaluate the performance and potential clinical role of three-dimensional (3D) 1060-nm OCT by generating choroidal thickness (ChT) maps in patients of different ages with different degrees of ametropia and axial lengths and to investigate the effect of cataract grade on OCT retinal imaging quality.
Axial lengths (ALs) and 45° fundus photographs were acquired from 64 eyes (34 healthy subjects, 19 to 80 years, ametropia +3 to -10 D). 3D 1060-nm OCT was performed over a 36° × 36° field of view with ∼7-μm axial resolution and up to 70 frames/s (512 A-scans/frame). ChT maps between retinal pigment epithelium and the choroidal-scleral interface, were generated and statistically analyzed. A further 30 eyes (19 subjects), with cataracts assessed with the LOCS III scale, were imaged with 3D 1060-nm OCT and 800-nm OCT, and visualization of the posterior segment was compared qualitatively.
In 64 eyes, ChT maps displayed a thickness decrease with increasing AL. Subfoveal ChT was 315 ± 106 μm (mean ± SD), negatively correlated with AL (R(2) = -0.47, P < 0.001). Averaged ChT maps of eyes with AL < 23.39 mm showed an increased ChT in an area ∼1500 μm inferior, compared with subfoveal ChT. Eyes with AL > 24.5 mm showed a larger variation and a thicker ChT superiorly than inferiorly. Reduced signal strength in cataractous eyes was found in 65% of the 800-nm OCT images, but in only 10% of the 1060-nm OCT images.
The imaging performance of 3D 1060-nm OCT is unique, producing maps that show the variation in ChT over the entire field of view, in relation to axial length. This imaging system has the potential of visualizing a novel clinical diagnostic biomarker. Compared with 800-nm OCT, it provides superior visualization of the posterior pole in cataractous eyes.
通过生成不同年龄、不同屈光不正程度和眼轴长度患者的脉络膜厚度（ChT）图，评估三维（3D）1060 nm光学相干断层扫描（OCT）的性能和潜在临床作用，并研究白内障分级对OCT视网膜成像质量的影响。
对64只眼（34名健康受试者，年龄19至80岁，屈光不正度数为+3至-10 D）测量眼轴长度（AL）并拍摄45°眼底照片。在36°×36°视野范围内进行3D 1060 nm OCT检查，轴向分辨率约为7μm，帧频高达70帧/秒（每帧512条A扫描线）。生成视网膜色素上皮与脉络膜-巩膜界面之间的ChT图并进行统计分析。另外对30只眼（19名受试者）用LOCS III量表评估白内障情况，分别用3D 1060 nm OCT和800 nm OCT进行成像，对后段的可视化情况进行定性比较。
在64只眼中，ChT图显示ChT随AL增加而降低。黄斑中心凹下ChT为315±106μm（平均值±标准差），与AL呈负相关（R²=-0.47，P<0.001）。AL<23.39 mm的眼平均ChT图显示，在黄斑中心凹下约1500μm处的区域ChT增加。AL>24.5 mm的眼显示出更大的差异，上方ChT比下方厚。在800 nm OCT图像中，65%的白内障眼信号强度降低，但在1060 nm OCT图像中仅为10%。
3D 1060 nm OCT的成像性能独特，能生成显示整个视野内ChT随眼轴长度变化的图。该成像系统有潜力可视化一种新的临床诊断生物标志物。与800 nm OCT相比，它能更好地显示白内障眼后极部的情况。
