School of Medicine, University of Electronic Science and Technology of China, No.23, West Section 2, 1St Ring Road, Qing Yang District, Chengdu City, 610072, Sichuan Province, China.
Department of Ophthalmology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, Sichuan, China.
Sci Rep. 2023 Jun 6;13(1):9215. doi: 10.1038/s41598-023-36374-z.
To evaluate the distribution of choroidal thickness (CT) and its trend with age in healthy people using 120° ultra-wide field swept-source optical coherence tomography angiography (UWF SS-OCTA). In this cross-sectional observational study, healthy volunteers underwent single imaging of the fundus with UWF SS-OCTA at a field of view (FOV) of 120° (24 mm × 20 mm) centered on the macula. The characteristics of CT distribution in different regions and its changes with age were analyzed. A total of 128 volunteers with a mean age of 34.9 ± 20.1 years and 210 eyes were enrolled in the study. The thickest mean choroid thickness (MCT) was located at the macular region and supratemporal region, followed by the nasal side of the optic disc, and thinnest below the optic disc. The maximum MCT was: 213.40 ± 36.65 μm for the group aged 20-29, and the minimum MCT was: 162.11 ± 31.96 μm for the group aged ≥ 60. After the age of 50, MCT was significantly and negatively correlated decreased with age (r = - 0.358, p = 0.002), and the MCT in the macular region decreased more remarkably compared to other regions. The 120° UWF SS-OCTA can observe the distribution of choroidal thickness in the range of 24 mm × 20 mm and its variation with age. It was revealed that MCT decreased more rapidly in the macular region relative to other regions after 50 years old.
利用 120°超广角扫频源光相干断层扫描血管造影（UWF SS-OCTA）评估正常人脉络膜厚度（CT）的分布及其随年龄的变化趋势。本横断面观察性研究中，健康志愿者接受了 UWF SS-OCTA 对黄斑中心 120°（24mm×20mm）视野的单次眼底成像。分析了不同区域 CT 分布特征及其随年龄的变化。共纳入 128 名平均年龄 34.9±20.1 岁的志愿者和 210 只眼。最厚的平均脉络膜厚度（MCT）位于黄斑区和颞上方，其次是视盘鼻侧，最薄的是视盘下方。20-29 岁组的最大 MCT 为 213.40±36.65μm，≥60 岁组的最小 MCT 为 162.11±31.96μm。50 岁后，MCT 与年龄呈显著负相关（r=-0.358，p=0.002），且黄斑区 MCT 下降更为明显。120°UWF SS-OCTA 可观察 24mm×20mm 范围内脉络膜厚度的分布及其随年龄的变化。结果显示，50 岁后黄斑区 MCT 较其他区域下降更为迅速。
