Department of Epidemiology and Biostatistics, The University of Western Ontario, Kresge Building, Room K201, London, ON, N6A 5C1, Canada.
Qual Life Res. 2010 Sep;19(7):955-64. doi: 10.1007/s11136-010-9660-2. Epub 2010 May 7.
To test whether elevated levels of depressive symptoms affect reports of child outcomes in a sample of mothers of children with new-onset epilepsy.
A sample of 339 mothers from the Health-related Quality of Life in Children with Epilepsy Study was used in the analysis. Mothers' depressive symptoms were measured using the Center for Epidemiological Studies Depression Scale (CES-D). To examine whether maternal mental health status moderated mothers' reports of each core domain of health-related quality of life (functional status, psychological functioning, social functioning, and disease state/symptoms), a series of multiple regression analyses was conducted. Interactions, depicted as product terms between CES-D scores and neurologist-reported measures, were used to determine the presence of depression distortion.
Interactions in the regression models were not significant with one exception in the functional status domain of mothers' assessments of their child's energy/fatigue and its impact on daily activities [beta = 0.24 (0.06, 0.41)]. Mothers with high levels of depressive symptoms were shown to have reported higher scores for their child's energy/fatigue and its impact on daily activities.
Results from this study do not suggest that the mental health status of mothers affects reporting on the domains of health-related quality of life for their children with new-onset epilepsy.
在新诊断癫痫儿童的母亲样本中，测试抑郁症状升高是否会影响儿童结局报告。
在《癫痫儿童健康相关生活质量研究》中使用了 339 名母亲的样本进行分析。使用《流行病学研究中心抑郁量表》（CES-D）来衡量母亲的抑郁症状。为了检验母亲的心理健康状况是否会影响其对健康相关生活质量的每个核心领域（功能状态、心理功能、社会功能和疾病状态/症状）的报告，进行了一系列多元回归分析。使用交互项（CES-D 评分和神经科医生报告的测量值的乘积项）来确定是否存在抑郁扭曲。
回归模型中的交互项除了一个例外均不显著，这个例外是在母亲对其孩子的精力/疲劳及其对日常活动的影响的功能状态领域[β=0.24（0.06，0.41）]。结果表明，抑郁症状水平较高的母亲报告其孩子的精力/疲劳及其对日常活动的影响得分更高。
本研究结果表明，母亲的心理健康状况不会影响其对新诊断癫痫儿童健康相关生活质量领域的报告。
