School of Public Health and Health Systems, University of Waterloo, 200 University Avenue West, Waterloo, ON, N2L 3G1, Canada.
Qual Life Res. 2019 Mar;28(3):703-712. doi: 10.1007/s11136-018-2026-x. Epub 2018 Oct 16.
The purpose of the study was to test whether elevated levels of depressive and anxiety symptoms affect parent-proxy reports of health-related quality of life (HRQL) of children with mental disorder.
A sample of 114 children, who screened positive for mental disorder using the Mini International Neuropsychiatric Interview were studied. Parents' depressive symptoms were measured using the Center for Epidemiological Studies Depression Scale (CES-D) and anxiety symptoms using the State Trait Anxiety Inventory (STAI). To examine whether parental psychopathology moderated their reports of child HRQL (using the KIDSCREEN-27), a series of multiple regression analyses with product-term interactions were conducted.
Significant interactions were found for the moderating effect of parental depressive [β = 0.025 (0.007, 0.042)] and anxiety symptoms [β = 0.033 (0.011, 0.054)] on the domain of child social support and peers relations, as well as for the moderating effect of parental levels of depression on parent proxy child physical well-being [β = - 0.017 (- 0.031, - 0.003)]. Parents with elevated levels of depressive or anxiety symptoms reported lower scores for those domains of child HRQL.
Symptoms of depression and anxiety in parents influence their reports of the HRQL of their children with mental disorder, particularly in the areas of physical well-being and social support and peers. Given the importance of patient-reported outcomes in the assessment and monitoring of children with chronic conditions, including HRQL, health professionals caring for children with mental disorder should be aware of how parental psychopathology contributes to informant bias. Future research examining why psychopathology influences parental reports of child HRQL is warranted.
本研究旨在检验抑郁和焦虑症状是否会影响患有精神障碍的儿童的父母报告其健康相关生活质量（HRQL）。
研究共纳入了 114 名经 Mini 国际神经精神访谈（MINI）筛查为患有精神障碍的儿童。采用流行病学研究中心抑郁量表（CES-D）和状态特质焦虑量表（STAI）来评估父母的抑郁症状和焦虑症状。为了检验父母的精神病理学是否调节了他们对儿童 HRQL 的报告（使用 KIDSCREEN-27），进行了一系列具有乘积项交互作用的多元回归分析。
在儿童社会支持和同伴关系这一领域，父母的抑郁症状（β=0.025（0.007，0.042））和焦虑症状（β=0.033（0.011，0.054））存在显著的调节作用，以及父母的抑郁水平对父母代理儿童生理健康的调节作用（β=-0.017（-0.031，-0.003））存在显著的交互作用。具有较高抑郁或焦虑症状的父母报告了较低的儿童 HRQL 得分。
父母的抑郁和焦虑症状会影响他们对患有精神障碍的儿童 HRQL 的报告，特别是在生理健康、社会支持和同伴关系方面。鉴于患者报告的结果在评估和监测患有慢性疾病（包括 HRQL）的儿童方面的重要性，照顾患有精神障碍的儿童的卫生保健专业人员应该意识到父母的精神病理学如何导致信息偏倚。未来的研究应进一步探讨为什么精神病理学会影响父母对儿童 HRQL 的报告。
