Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC 28232, USA
Support Care Cancer. 2010 Aug;18(8):1007-21. doi: 10.1007/s00520-010-0873-2. Epub 2010 May 7.
This purpose of this systematic review was to evaluate the literature and update our current understanding of the impact of present cancer therapies on the dental apparatus (teeth and periodontium) since the 1989 NIH Development Consensus Conference on the Oral Complications of Cancer Therapies.
A systematic literature search was conducted with assistance from a research librarian in the databases MEDLINE/PubMed and EMBASE for articles published between 1 January 1990 and 31 December 2008. Each study was independently assessed by two reviewers. Taking into account predetermined quality measures, a weighted prevalence was calculated for the prevalence of dental caries, severe gingival disease, and dental infection. Data on DMFT/dmft, DMFS/dmfs, plaque, and gingival indexes were also gathered. The level of evidence, recommendation, and guideline (if possible) were given for published preventive and management strategies.
Sixty-four published papers between 1990 and 2008 were reviewed. The weighted overall prevalence of dental caries was 28.1%. The overall DMFT for patients who were post-antineoplastic therapy was 9.19 (SD, 7.98; n = 457). The overall plaque index for patients who were post-antineoplastic therapy was 1.38 (SD, 0.25; n = 189). The GI for patients who were post-chemotherapy was 1.02 (SD, 0.15; n = 162). The weighted prevalence of dental infections/abscess during chemotherapy was reported in three studies and was 5.8%.
Patients who were post-radiotherapy had the highest DMFT. The use of fluoride products and chlorhexidine rinses are beneficial in patients who are post-radiotherapy. There continues to be lack of clinical studies on the extent and severity of dental disease that are associated with infectious complications during cancer therapy.
本系统综述的目的是评估自 1989 年 NIH 癌症治疗口腔并发症发展共识会议以来，当前癌症治疗对牙齿和牙周组织（牙和牙周组织）的影响的文献，并更新我们目前的认识。
在研究图书馆员的协助下，我们在 MEDLINE/PubMed 和 EMBASE 数据库中进行了系统的文献检索，以检索 1990 年 1 月 1 日至 2008 年 12 月 31 日期间发表的文章。每篇文章均由两名评审员独立评估。考虑到预定的质量标准，计算了龋齿、严重牙龈炎和牙齿感染的患病率的加权患病率。还收集了 DMFT/dmft、DMFS/dmfs、菌斑和牙龈指数的数据。对于已发表的预防和管理策略，给出了证据水平、建议和指南（如果可能）。
在 1990 年至 2008 年期间共审查了 64 篇已发表的论文。龋齿的加权总患病率为 28.1%。接受抗肿瘤治疗后患者的总体 DMFT 为 9.19（SD，7.98；n=457）。接受抗肿瘤治疗后患者的总体菌斑指数为 1.38（SD，0.25；n=189）。接受化疗的患者的 GI 为 1.02（SD，0.15；n=162）。在三项研究中报告了化疗期间牙齿感染/脓肿的加权患病率，为 5.8%。
接受放疗的患者 DMFT 最高。在接受放疗的患者中，使用氟化物产品和洗必泰漱口液是有益的。在癌症治疗期间与感染并发症相关的牙齿疾病的程度和严重程度的临床研究仍然缺乏。
