Institute for Radiological Protection and Nuclear Safety, Radiological Protection and Human Health Division, Radiobiology and Epidemiology Department, Laboratory of Experimental Toxicology, BP 17, 92262 Fontenay-aux-Roses cedex, France.
C R Biol. 2010 May;333(5):416-23. doi: 10.1016/j.crvi.2010.02.003. Epub 2010 Apr 24.
The testis is especially sensitive to pollutants, including radionuclides. Following the Chernobyl nuclear power plant accident, several of these radionuclides were emitted and spread in the environment. Subsequently, children presented some disruptions of the endocrine system. To determine whether these disruptions were due to 137 cesium ((137)Cs) exposure, the effects of chronic contamination with low doses of (137)Cs in utero or from birth on testicular steroidogenesis in rats were studied. Contamination was continued for 9 months. No modification was observed in circulating level of hormones (17beta-estradiol, testosterone, follicle-stimulating hormone, luteinizing hormone) following in utero or post-natal contamination. Expression of several genes involved in testicular steroidogenesis was affected (cyp19a1, fxr, sf-1), without modification of protein expression or activity. Our results suggest that growing organisms may be affected at the molecular level by (137)Cs contamination at this post-accidental dose.
睾丸对污染物特别敏感，包括放射性核素。在切尔诺贝利核电站事故之后，其中一些放射性核素被排放并在环境中扩散。随后，儿童的内分泌系统出现了一些紊乱。为了确定这些紊乱是否是由于 137 铯（137Cs）暴露引起的，研究了宫内或出生后低剂量慢性接触 137Cs 对大鼠睾丸类固醇生成的影响。污染持续了 9 个月。在宫内或产后污染后，激素（17β-雌二醇、睾酮、卵泡刺激素、黄体生成素）的循环水平没有观察到变化。参与睾丸类固醇生成的几个基因的表达受到影响（cyp19a1、fxr、sf-1），但蛋白质表达或活性没有改变。我们的结果表明，在这种事故后剂量下，生长中的生物体可能会在分子水平上受到 137Cs 污染的影响。
