Internistische Klinik Dr. Müller, München, Germany.
Eur J Med Res. 2010 Mar 30;15(3):124-30. doi: 10.1186/2047-783x-15-3-124.
Gastro-oesophageal reflux disease (GERD) is a common disorder with consequences for the patient's health-related quality of life (HRQoL). In Germany, few data are available on the impact of GERD on work-related productivity.
To study the impact of GERD on work productivity despite proton pump inhibitor (PPI) therapy and the association between productivity and symptom duration, severity, and HRQoL.
Retrospective data from randomly selected patients with chronic GERD symptoms, treated by office-based general practitioners or general internists with routine clinical care, were analyzed together with information from self-administered instruments assessing work productivity (WPAI-GERD), symptoms (RDQ), and HRQoL (QOLRAD).
Reduced productivity was reported by 152 of 249 patients (61.0%), although 89.5% of them were treated with PPI. The reduction in work productivity was 18.5% in all patients and 30.3% in those with reduced productivity. Patients with impaired productivity showed a significantly lower HRQoL and more-severe symptoms of reflux disease. In all patients, the mean sick leave attributable to reflux symptoms was 0.6 hours in the previous seven days and 1.4 work days in the previous three months.
GERD has a substantial impact on work productivity in Germany, even in patients receiving routine clinical care and PPI therapy.
胃食管反流病（GERD）是一种常见疾病，会对患者的健康相关生活质量（HRQoL）产生影响。在德国，关于 GERD 对工作相关生产力的影响的数据很少。
研究尽管接受质子泵抑制剂（PPI）治疗，GERD 对工作生产力的影响，以及生产力与症状持续时间、严重程度和 HRQoL 之间的关系。
对随机选择的患有慢性 GERD 症状的患者进行回顾性数据分析，这些患者由门诊普通科医生或普通内科医生进行常规临床治疗，并结合自我管理工具评估工作生产力（WPAI-GERD）、症状（RDQ）和 HRQoL（QOLRAD）的信息进行分析。
尽管 89.5%的患者接受了 PPI 治疗，但仍有 249 名患者中的 152 名（61.0%）报告生产力下降。所有患者的工作生产力下降了 18.5%，生产力下降的患者下降了 30.3%。生产力受损的患者 HRQoL 明显较低，反流疾病的症状更严重。在所有患者中，过去七天内因反流症状而请病假的平均时间为 0.6 小时，过去三个月内请病假的平均工作天数为 1.4 天。
即使在接受常规临床护理和 PPI 治疗的患者中，GERD 对德国的工作生产力也有重大影响。
