咖啡和咖啡因对正常志愿者的血流动力学影响：一项安慰剂对照的临床研究。

Haemodynamic effects of coffee and caffeine in normal volunteers: a placebo-controlled clinical study.

作者信息

Casiglia E, Bongiovì S, Paleari C D, Petucco S, Boni M, Colangeli G, Penzo M, Pessina A C

机构信息

Medical Clinic, University of Padova, Italy.

出版信息

J Intern Med. 1991 Jun;229(6):501-4. doi: 10.1111/j.1365-2796.1991.tb00385.x.

DOI:10.1111/j.1365-2796.1991.tb00385.x

PMID:2045756

Abstract

The acute haemodynamic effects of Italian coffee and 200 mg purified caffeine were investigated in 15 healthy non-coffee-drinkers compared to individuals who consumed placebo (highly decaffeinated coffee for regular coffee, and china bitter extract for caffeine). Before coffee and caffeine consumption and 30, 60, 90 and 120 min afterwards, rest flow and blood pressure were measured, and peripheral resistance in the arm was calculated; an echocardiogram was also performed before and 60 and 120 min after caffeine consumption. Both coffee and caffeine significantly decreased rest flow, and increased peripheral resistance. Systolic blood pressure increased by 10% and diastolic pressure increased by 5% for at least 2 h. No variation in heart rate or cardiac contractility was found. No effects were observed after placebo treatment. It is concluded that Italian coffee and caffeine increase blood pressure via vasoconstriction.

摘要

在15名不喝咖啡的健康受试者中，研究了意大利咖啡和200毫克纯化咖啡因的急性血流动力学效应，并与服用安慰剂（用高度脱咖啡因咖啡替代普通咖啡，用中国苦提取物替代咖啡因）的受试者进行了比较。在饮用咖啡和咖啡因之前以及之后30、60、90和120分钟，测量静息血流和血压，并计算手臂的外周阻力；在饮用咖啡因之前以及之后60和120分钟还进行了超声心动图检查。咖啡和咖啡因均显著降低静息血流，并增加外周阻力。收缩压至少升高10%，舒张压至少升高5%，持续至少2小时。未发现心率或心脏收缩力有变化。安慰剂治疗后未观察到任何效果。结论是，意大利咖啡和咖啡因通过血管收缩升高血压。