丙型肝炎病毒：病毒颗粒的组装和释放。
Hepatitis C virus: assembly and release of virus particles.
机构信息
Medical Research Council Virology Unit, Church Street, Glasgow G11 5JR, Scotland, United Kingdom.
出版信息
J Biol Chem. 2010 Jul 23;285(30):22733-9. doi: 10.1074/jbc.R110.133017. Epub 2010 May 10.
Abstract
Hepatitis C virus is a blood-borne virus that typically establishes a chronic infection in the liver, which often results in cirrhosis and hepatocellular carcinoma. Progress in understanding the complete virus life cycle has been greatly enhanced by the recent availability of a tissue culture system that produces infectious virus progeny. Thus, it is now possible to gain insight into the roles played by viral components in assembly and egress and the cellular pathways that contribute to virion formation. This minireview describes the key determining viral and host factors that are needed to produce infectious virus.
摘要
丙型肝炎病毒是一种血源性病原体，通常在肝脏中建立慢性感染，这通常会导致肝硬化和肝细胞癌。最近，一种能够产生感染性病毒后代的组织培养系统的出现，极大地促进了对完整病毒生命周期的理解。因此，现在有可能深入了解病毒成分在组装和出芽过程中以及有助于病毒形成的细胞途径所起的作用。这篇综述描述了产生感染性病毒所需的关键决定病毒和宿主因素。
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