Zwartjes Daphne G M, Heida Tjitske, van Vugt Jeroen P P, Geelen Jan A G, Veltink Peter H
IEEE Trans Biomed Eng. 2010 Nov;57(11). doi: 10.1109/TBME.2010.2049573. Epub 2010 May 10.
Ambulatory monitoring of motor symptoms in Parkinsons disease (PD) can improve our therapeutic strategies, especially in patients with motor fluctuations. Previously published monitors usually assess only one or a few basic aspects of the cardinal motor symptoms in a laboratory setting. We developed a novel ambulatory monitoring system that provides a complete motor assessment by simultaneously analyzing current motor activity of the patient (e.g. sitting, walking) and the severity of many aspects related to tremor, bradykinesia, and hypokinesia. The monitor consists of a set of four inertial sensors. Validity of our monitor was established in seven healthy controls and six PD patients treated with deep brain stimulation (DBS) of the subthalamic nucleus. Patients were tested at three different levels of DBS treatment. Subjects were monitored while performing different tasks, including motor tests of the Unified Parkinsons Disease Rating Scale (UPDRS). Output of the monitor was compared to simultaneously recorded videos. The monitor proved very accurate in discriminating between several motor activities. Monitor output correlated well with blinded UPDRS ratings during different DBS levels. The combined analysis of motor activity and symptom severity by our PD monitor brings true ambulatory monitoring of a wide variety of motor symptoms one step closer..
帕金森病（PD）运动症状的动态监测可改善我们的治疗策略，尤其是对于存在运动波动的患者。先前发表的监测仪通常仅在实验室环境中评估主要运动症状的一个或几个基本方面。我们开发了一种新型动态监测系统，通过同时分析患者当前的运动活动（如坐姿、行走）以及与震颤、运动迟缓、运动减退相关的多个方面的严重程度，提供全面的运动评估。该监测仪由一组四个惯性传感器组成。我们在7名健康对照者和6名接受丘脑底核深部脑刺激（DBS）治疗的PD患者中验证了监测仪的有效性。对患者在三种不同的DBS治疗水平下进行测试。在受试者执行不同任务时进行监测，包括统一帕金森病评定量表（UPDRS）的运动测试。将监测仪的输出与同时录制的视频进行比较。该监测仪在区分几种运动活动方面证明非常准确。在不同的DBS水平下，监测仪的输出与盲法UPDRS评分具有良好的相关性。我们的PD监测仪对运动活动和症状严重程度的综合分析使对多种运动症状的真正动态监测又向前迈进了一步。
