Cox A D, Wilkinson S G
School of Chemistry, University of Hull, UK.
Mol Microbiol. 1991 Mar;5(3):641-6. doi: 10.1111/j.1365-2958.1991.tb00735.x.
Contrary to previous reports, lipopolysaccharides from Pseudomonas cepacia contain a 3-deoxyoct-2-ulosonic acid (probably a single residue). The lipopolysaccharides contain only two phosphate residues, one of which apparently forms a phosphodiester bridge between 4-amino-4-deoxyarabinose and a glucosamine residue in lipid A. The second, unlocated phosphate residue occurs mainly as a monoester in some lipopolysaccharides, and mainly as a diester in others. All lipopolysaccharides lack pyrophosphate residues. The results support the view that the resistance of P. cepacia to cationic antibiotics stems from ineffective binding to the outer membrane, as a consequence of the low number of phosphate and carboxylate groups in the lipopolysaccharide, and the presence of the protonated aminodeoxypentose.
与之前的报道相反，洋葱伯克霍尔德菌的脂多糖含有3-脱氧辛-2-酮糖酸（可能为单个残基）。这些脂多糖仅含有两个磷酸残基，其中一个显然在脂质A中4-氨基-4-脱氧阿拉伯糖和一个葡糖胺残基之间形成磷酸二酯桥。第二个未定位的磷酸残基在一些脂多糖中主要以单酯形式存在，而在其他脂多糖中主要以二酯形式存在。所有脂多糖均缺乏焦磷酸残基。这些结果支持以下观点：洋葱伯克霍尔德菌对阳离子抗生素的抗性源于与外膜的结合无效，这是由于脂多糖中磷酸和羧基基团数量较少以及质子化氨基脱氧戊糖的存在所致。
