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瑞香素是一种天然存在的酚类化合物，通过阻断 NF-κB 激活途径抑制 LPS 诱导的 RAW264.7 细胞中 iNOS 和 COX-2 的表达。

Rheosmin, a naturally occurring phenolic compound inhibits LPS-induced iNOS and COX-2 expression in RAW264.7 cells by blocking NF-kappaB activation pathway.

机构信息

Bioresource Sciences, Andong National University, Andong 760749, Republic of Korea.

出版信息

Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2148-53. doi: 10.1016/j.fct.2010.05.020. Epub 2010 May 15.

DOI:10.1016/j.fct.2010.05.020
PMID:20478352
Abstract

Inflammation is part of the host defense mechanism against harmful matters and injury; however, aberrant inflammation is associated to the development of chronic disease such as cancer. Raspberry ketone is a natural phenolic compound. It is used in perfumery, in cosmetics, and as a food additive to impart a fruity odor. In this study, we evaluated whether rheosmin, a phenolic compound isolated from pine needles regulates the expression of iNOS and COX-2 protein in LPS-stimulated RAW264.7 cells. Rheosmin dose-dependently inhibited NO and PGE(2) production and also blocked LPS-induced iNOS and COX-2 expression. Rheosmin potently inhibited the translocation of NF-kappaB p65 into the nucleus by IkappaB degradation following IkappaB-alpha phosphorylation. This result shows that rheosmin inhibits NF-kappaB activation. In conclusion, our results suggest that rheosmin inhibits LPS-induced iNOS and COX-2 expression in RAW264.7 cells by blocking NF-kappaB activation pathway.

摘要

炎症是宿主防御机制对抗有害物质和损伤的一部分；然而，异常炎症与癌症等慢性疾病的发展有关。树莓酮是一种天然酚类化合物。它用于香水、化妆品，并作为食品添加剂赋予水果味香气。在这项研究中，我们评估了从松针中分离出的酚类化合物 rheosmin 是否调节 LPS 刺激的 RAW264.7 细胞中 iNOS 和 COX-2 蛋白的表达。Rheosmin 呈剂量依赖性抑制 NO 和 PGE（2）的产生，并阻断 LPS 诱导的 iNOS 和 COX-2 的表达。Rheosmin 通过 IkappaB-α磷酸化导致 IkappaB 降解，从而强烈抑制 NF-kappaB p65 向核内易位。该结果表明 rheosmin 抑制 NF-kappaB 的激活。总之，我们的结果表明，rheosmin 通过阻断 NF-kappaB 激活途径抑制 LPS 诱导的 RAW264.7 细胞中 iNOS 和 COX-2 的表达。

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