模拟具有特定个体边界条件的肺部气流。
Simulation of pulmonary air flow with a subject-specific boundary condition.
机构信息
Department of Mechanical and Industrial Engineering, The University of Iowa, Iowa City, Iowa, USA.
出版信息
J Biomech. 2010 Aug 10;43(11):2159-63. doi: 10.1016/j.jbiomech.2010.03.048. Epub 2010 May 18.
Abstract
We present a novel image-based technique to estimate a subject-specific boundary condition (BC) for computational fluid dynamics (CFD) simulation of pulmonary air flow. The information of regional ventilation for an individual is derived by registering two computed tomography (CT) lung datasets and then passed to the CT-resolved airways as the flow BC. The CFD simulations show that the proposed method predicts lobar volume changes consistent with direct image-measured metrics, whereas the other two traditional BCs (uniform velocity or uniform pressure) yield lobar volume changes and regional pressure differences inconsistent with observed physiology.
摘要
我们提出了一种新的基于图像的技术，用于估计计算流体动力学 (CFD) 模拟肺气流的特定于主体的边界条件 (BC)。通过注册两个计算断层扫描 (CT) 肺部数据集，可以获得个体的区域通气信息，然后将其传递到 CT 解析气道作为流动 BC。CFD 模拟表明，所提出的方法预测的肺叶体积变化与直接图像测量的指标一致，而其他两种传统的 BC（均匀速度或均匀压力）产生的肺叶体积变化和区域压力差与观察到的生理情况不一致。
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本文引用的文献
1
Evaluation of lobar biomechanics during respiration using image registration.
Med Image Comput Comput Assist Interv. 2009;12(Pt 1):739-46. doi: 10.1007/978-3-642-04268-3_91.
2
Airway wall stiffening increases peak wall shear stress: a fluid-structure interaction study in rigid and compliant airways.
Ann Biomed Eng. 2010 May;38(5):1836-53. doi: 10.1007/s10439-010-9956-y. Epub 2010 Feb 17.
3
What drives the peripheral lung-remodeling process in chronic obstructive pulmonary disease?
Proc Am Thorac Soc. 2009 Dec;6(8):668-72. doi: 10.1513/pats.200907-079DP.
4
On intra- and intersubject variabilities of airflow in the human lungs.
Phys Fluids (1994). 2009 Oct;21(10):101901. doi: 10.1063/1.3247170. Epub 2009 Oct 13.
5
Mass preserving nonrigid registration of CT lung images using cubic B-spline.
Med Phys. 2009 Sep;36(9):4213-22. doi: 10.1118/1.3193526.
6
Supine and prone differences in regional lung density and pleural pressure gradients in the human lung with constant shape.
J Appl Physiol (1985). 2009 Sep;107(3):912-20. doi: 10.1152/japplphysiol.00324.2009. Epub 2009 Jul 9.
7
The effects of geometry on airflow in the acinar region of the human lung.
J Biomech. 2009 Aug 7;42(11):1635-42. doi: 10.1016/j.jbiomech.2009.04.046. Epub 2009 May 31.
8
Computational fluid dynamics.
IEEE Eng Med Biol Mag. 2009 May-Jun;28(3):25-33. doi: 10.1109/MEMB.2009.932480.
9
CFD simulation of aerosol deposition in an anatomically based human large-medium airway model.
Ann Biomed Eng. 2009 Feb;37(2):271-85. doi: 10.1007/s10439-008-9620-y. Epub 2008 Dec 12.
10
Numerical investigation of the three-dimensional flow in a human lung model.
J Biomech. 2008 Aug 7;41(11):2446-57. doi: 10.1016/j.jbiomech.2008.05.016. Epub 2008 Jul 9.
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