Reinhardt Joseph M, Christensen Gary E, Hoffman Eric A, Ding Kai, Cao Kunlin
Department of Biomedical Engineering, The University of Iowa, Iowa City, IA 52242, USA.
Inf Process Med Imaging. 2007;20:763-74. doi: 10.1007/978-3-540-73273-0_63.
The main function of the respiratory system is gas exchange. Since many disease or injury conditions can cause biomechanical or material property changes that can alter lung function, there is a great interest in measuring regional lung ventilation. We describe a registration-based technique for estimating local lung expansion from multiple respiratory-gated CT images of the thorax. The degree of regional lung expansion is measured using the Jacobian of the registration displacement field. We compare lung expansion estimated across five pressure changes to a xenon CT based measure of specific ventilation, and have shown good agreement (linear regression, r2 = 0.89 during gas wash-in) in one animal.
呼吸系统的主要功能是气体交换。由于许多疾病或损伤情况会导致生物力学或材料特性的改变，进而影响肺功能，因此人们对测量局部肺通气量有着浓厚的兴趣。我们描述了一种基于配准的技术，用于从胸部的多个呼吸门控CT图像估计局部肺扩张情况。使用配准位移场的雅可比行列式来测量局部肺扩张程度。我们将在五种压力变化下估计的肺扩张情况与基于氙CT的比通气量测量值进行了比较，并且在一只动物身上显示出了良好的一致性（线性回归，气体吸入期间r2 = 0.89）。
