Discipline of Paediatrics, The University of Queensland Royal Children's Hospital, Queensland, Australia.
Am J Clin Nutr. 2010 Jul;92(1):55-60. doi: 10.3945/ajcn.2010.29201. Epub 2010 May 19.
Nutritional status, as represented by body composition, is an important consideration in the treatment of pediatric cancer patients because it is linked to poor outcomes. Little is known about how a child's body composition responds to cancer and treatment.
We aimed to compare the body composition of children undergoing treatment of cancer with that of healthy controls and to compare body composition between children with hematologic malignancies and children with solid tumors.
This cross-sectional study measured height, weight, body cell mass, fat-free mass, and fat mass in 48 children undergoing treatment of cancer and blood-related disorders and in age-matched healthy controls.
Patients with cancer had a significantly lower body cell mass index z score (body cell mass/height raised to the power of 2.5 for females and 3 for males) than did controls (P = 0.0001), and 45% of the patients with cancer were considered malnourished according to body cell mass. Subjects with cancer had a significantly higher percentage of body fat (P = 0.0001) and fat mass (P = 0.0001) than did controls; however, there was no significant difference in fat-free mass (P = 0.09). On the basis of percentage fat, 77% of subjects with cancer were considered obese. No difference in body composition was observed between cancer types.
This study showed that children undergoing treatment of all types of cancer have a significantly lower body cell mass and a significantly higher fat mass than do healthy controls. Nutritional support is suggested for all children undergoing treatment of cancer.
营养状况，以身体成分来表示，是治疗儿科癌症患者时需要考虑的一个重要因素，因为它与不良预后有关。目前对于儿童的身体成分如何对癌症及其治疗产生反应知之甚少。
我们旨在比较正在接受癌症治疗的儿童与健康对照组的身体成分，并比较血液系统恶性肿瘤患儿与实体瘤患儿之间的身体成分。
这项横断面研究测量了 48 名正在接受癌症和血液相关疾病治疗的儿童以及年龄匹配的健康对照组的身高、体重、细胞内液量、去脂体重和脂肪量。
癌症患者的细胞内液量指数 z 评分（女性为细胞内液量/身高的 2.5 次方，男性为 3 次方）显著低于对照组（P = 0.0001），根据细胞内液量，有 45%的癌症患者被认为存在营养不良。癌症患者的体脂百分比（P = 0.0001）和脂肪量（P = 0.0001）显著高于对照组；然而，去脂体重（P = 0.09）无显著差异。基于体脂百分比，77%的癌症患者被认为肥胖。癌症类型之间的身体成分无差异。
本研究表明，正在接受各种癌症治疗的儿童的细胞内液量显著降低，脂肪量显著增加，而与健康对照组相比。建议所有接受癌症治疗的儿童都接受营养支持。
