Department of Preventive Medicine, Medical School Building A-Room 512, College of Medicine, Hanyang University, 17 Haengdang Dong, Sungdong Gu, Seoul 133-791, South Korea.
Br J Nutr. 2010 Oct;104(8):1202-11. doi: 10.1017/S0007114510001893. Epub 2010 May 21.
The relationship between dietary Zn intake and the risk of atherosclerosis remains unclear, and no epidemiological studies have been reported on the effects of dietary Zn intake on morphological changes in the vascular wall. We examined the relationship between dietary Zn intake and common carotid intima-media thickness (IMT) as a marker of subclinical atherosclerosis among the middle-aged and elderly populations. A cross-sectional analysis of a prospective cohort baseline study was performed with 4564 adults aged 40-89 years and free of clinical CVD. Dietary data were collected by trained interviewers using an FFQ. Common carotid IMT was measured using a B-mode ultrasound imaging technique. Subclinical atherosclerosis was determined using carotid IMT, and defined as > 80th percentile of carotid IMT or ≥ 1 mm of carotid IMT. After adjustment for potential confounders, the mean carotid IMT in the low Zn intake group was higher than that in the high Zn intake group. When subclinical atherosclerosis was defined as > 80th percentile value of IMT or ≥ 1 mm of carotid IMT, after adjustment for potential confounders, Zn intake was inversely related to subclinical atherosclerosis (5th v. 1st quintile, OR 0.64, 95% CI 0.45, 0.90, P for trend = 0.069; 5th v. 1st quintile, OR 0.34, 95% CI 0.16, 0.70, P for trend = 0.005, respectively). In persons free of clinical CVD, dietary Zn intake was inversely correlated with subclinical atherosclerosis. The present findings suggest a putative protective role of dietary Zn intake against the development of atherosclerosis.
膳食锌摄入与动脉粥样硬化风险之间的关系尚不清楚，也没有关于膳食锌摄入对血管壁形态变化影响的流行病学研究。我们研究了膳食锌摄入与中老年人群亚临床动脉粥样硬化的颈总动脉内膜-中层厚度（IMT）之间的关系。对一项前瞻性队列研究的基线进行了横断面分析，共纳入了 4564 名年龄在 40-89 岁且无临床心血管疾病的成年人。通过受过培训的访谈者使用 FFQ 收集膳食数据。使用 B 型超声成像技术测量颈总动脉 IMT。通过颈动脉 IMT 确定亚临床动脉粥样硬化，并定义为颈动脉 IMT ＞第 80 百分位数或颈动脉 IMT≥1mm。在校正潜在混杂因素后，低锌摄入组的平均颈动脉 IMT 高于高锌摄入组。当亚临床动脉粥样硬化定义为 IMT ＞第 80 百分位数或颈动脉 IMT≥1mm 时，在校正潜在混杂因素后，锌摄入与亚临床动脉粥样硬化呈负相关（第 5 五分位与第 1 五分位相比，OR0.64，95%CI0.45-0.90，P 趋势=0.069；第 5 五分位与第 1 五分位相比，OR0.34，95%CI0.16-0.70，P 趋势=0.005）。在无临床心血管疾病的人群中，膳食锌摄入与亚临床动脉粥样硬化呈负相关。本研究结果提示膳食锌摄入可能对动脉粥样硬化的发生具有保护作用。
