Northwestern University Feinberg School of Medicine, Department of Obstetrics and Gynecology, Division of Fertility Preservation, 303 East Superior Street, Lurie 10-119, Chicago, IL 60211, USA.
Nat Rev Clin Oncol. 2010 Aug;7(8):466-75. doi: 10.1038/nrclinonc.2010.81. Epub 2010 May 25.
The number of young cancer survivors is increasing owing to advances in cancer therapeutics, but many face infertility as a result of their treatment. Technologies that already exist for cancer patients concerned about their future fertility include sperm banking for men and hormonal intervention followed by in vitro fertilization and embryo cryopreservation for women. However, logistical barriers to timely patient referral and coordination of care between specialties can limit patient access to all the available options. Moreover, there are few alternatives for young women and girls who cannot delay their cancer treatment, or who are unable to undergo hormonal intervention. The Oncofertility Consortium is a network of researchers, physicians and scholars who are advancing fertility preservation options for young cancer patients. Research into the societal, ethical, and legal implications is also an important part of the work performed by the Oncofertility Consortium, which is providing new perspectives on patient decision-making about how to access these emerging reproductive technologies. Experts in the fields of oncology, reproductive medicine, the social sciences, law, education, and the humanities are working together to develop next-generation reproductive interventions and promote communication between scholars, clinicians, patients, and the public to ensure that young cancer patients are equipped with the most appropriate information and options for having a family in the future.
由于癌症治疗方法的进步,年轻的癌症幸存者人数正在增加,但许多人因治疗而面临不孕。已经存在一些针对担心未来生育能力的癌症患者的技术,包括男性的精子库存储和女性的激素干预,随后进行体外受精和胚胎冷冻保存。然而,由于专科之间及时转诊和协调护理方面的后勤障碍,可能会限制患者获得所有可用选择的机会。此外,对于不能延迟癌症治疗或无法进行激素干预的年轻女性和女孩来说,几乎没有其他选择。Oncofertility 联盟是一个由研究人员、医生和学者组成的网络,他们正在为年轻癌症患者提供更多的生育力保存选择。对社会、伦理和法律影响的研究也是 Oncofertility 联盟工作的重要组成部分,该联盟为患者如何利用这些新兴的生殖技术做出决策提供了新的视角。肿瘤学、生殖医学、社会科学、法律、教育和人文学科的专家正在共同努力开发下一代生殖干预措施,并促进学者、临床医生、患者和公众之间的沟通,以确保年轻的癌症患者能够获得最适合他们的信息和选择,以便在未来拥有家庭。