从印度尼西亚海洋海绵卡特海绵（Carteriospongia foliascens）中分离出的基于半日花烷的倍半萜RCE蛋白酶抑制剂。

Scalarane-based sesterterpenoid RCE-protease inhibitors isolated from the Indonesian marine sponge Carteriospongia foliascens.

作者信息

Williams David E, Hollander Irwin, Feldberg Larry, Frommer Eileen, Mallon Robert, Tahir Akbar, van Soest Rob, Andersen Raymond J

机构信息

Department of Chemistry, University of British Columbia, Vancouver, BC, Canada.

出版信息

J Nat Prod. 2009 Jun;72(6):1106-9. doi: 10.1021/np900042r.

DOI:10.1021/np900042r

PMID:19485329

Abstract

Two new 20,24-bishomo-25-norscalaranes, compounds 1 and 2, and two new and two known 20,24-bishomoscalaranes, compounds 3-6, have been isolated from the Indonesian marine sponge Carteriospongia foliascens. The structures of 1-6 were determined by spectroscopic analysis. Compounds 1 and 3-6 inhibit RCE-protease activity.

摘要

从印度尼西亚海洋海绵叶状卡特海绵中分离出了两种新的20,24-双高-25-降卡拉烷类化合物，即化合物1和2，以及两种新的和两种已知的20,24-双高卡拉烷类化合物，即化合物3-6。通过光谱分析确定了化合物1-6的结构。化合物1和3-6可抑制RCE蛋白酶活性。