Eggers H J, Weyer J J
Institut für Virologie, Universität zu Köln, Germany.
Infection. 1991 Mar-Apr;19(2):115-22. doi: 10.1007/BF01645581.
Through epidemiological considerations we conclude that full-blown AIDS may occur only if the index patient is infected by the human immunodeficiency virus (HIV) and, in addition, by some other infectious coagent. Since the dynamical behavior of the spread of AIDS cases with manifestation of Kaposi's sarcoma differs fundamentally from that of the non-Kaposi cases, we conjecture that two independent coagents (together with HIV) are responsible for the outbreak of full-blown AIDS with or without manifestation of Kaposi's sarcoma, respectively. Our formal epidemiological considerations appear to be supported by recent microbiological findings.
通过流行病学考量,我们得出结论:只有当索引患者感染了人类免疫缺陷病毒(HIV),并且此外还感染了某种其他传染性协同因子时,才可能出现全面发作的艾滋病。由于伴有卡波西肉瘤表现的艾滋病病例传播的动态行为与非卡波西病例的动态行为根本不同,我们推测两种独立的协同因子(与HIV一起)分别导致了伴有或不伴有卡波西肉瘤表现的全面发作的艾滋病的爆发。我们正式的流行病学考量似乎得到了近期微生物学发现的支持。