Neuropaediatrics, Department of Paediatrics, University Children's Hospital, Inselspital, Bern, Switzerland.
Infection. 2010 Oct;38(5):413-6. doi: 10.1007/s15010-010-0028-x. Epub 2010 May 27.
Acute transverse myelitis (ATM) is a rare disorder (1-8 new cases per million of population per year), with 20% of all cases occurring in patients younger than 18 years of age. Diagnosis requires clinical symptoms and evidence of inflammation within the spinal cord (cerebrospinal fluid and/or magnetic resonance imaging). ATM due to neuroborreliosis typically presents with impressive clinical manifestations.
Here we present a case of Lyme neuroborreliosis-associated ATM with severe MRI and CSF findings, but surprisingly few clinical manifestations and late conversion of the immunoglobulin G CSF/blood index of Borrelia burgdorferi sensu lato.
Clinical symptoms and signs of neuroborrelial ATM may be minimal, even in cases with severe involvement of the spine, as shown by imaging studies. The CSF/blood index can be negative in the early stages and does not exclude Lyme neuroborreliosis; if there is strong clinical suspicion of Lyme neuroborreliosis, appropriate treatment should be started and the CSF/blood index repeated to confirm the diagnosis.
急性横贯性脊髓炎(ATM)是一种罕见疾病(每年每百万人口中有 1-8 例新发病例),其中 20%的病例发生在 18 岁以下的患者中。诊断需要临床症状和脊髓内炎症的证据(脑脊液和/或磁共振成像)。由神经伯氏疏螺旋体引起的 ATM 通常表现出明显的临床表现。
这里我们介绍一例莱姆病相关 ATM,其 MRI 和 CSF 结果严重,但临床表现出奇地少,而且伯氏疏螺旋体 IgG 脑脊液/血液指数的转换很晚。
即使在影像学显示脊柱严重受累的情况下,神经伯氏疏螺旋体 ATM 的临床症状和体征也可能很轻微。CSF/血液指数在早期可能为阴性,不能排除莱姆神经疏螺旋体病;如果强烈怀疑莱姆神经疏螺旋体病,应开始适当的治疗,并重复 CSF/血液指数以确认诊断。