多层聚电解质包覆的金纳米棒作为多功能光学对比剂用于癌细胞成像。
Multilayered polyelectrolyte-coated gold nanorods as multifunctional optical contrast agents for cancer cell imaging.
机构信息
Centre for Optical and Electromagnetic Research, State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310058, China.
出版信息
J Zhejiang Univ Sci B. 2010 Jun;11(6):417-22. doi: 10.1631/jzus.B0910731.
Abstract
We report the application of multilayered polyelectrolyte-coated gold nanorods (GNRs) as multifunctional optical contrast agents for cancer cell imaging. The surface modification of GNRs improves their chemical stability and facilitates them to be taken up by cancer cells through electrostatic interaction. The unique longitudinal surface plasmon resonance property of GNRs makes them suitable as both "scattering contrast agents" and "Raman contrast agents". In our experiments, the staining of GNRs in cells was further confirmed by dark field microscopy and Raman microscopy. Our experiment results indicated that GNRs have great potential as multifunctional "optical contrast agents" for future in vivo animal imaging.
摘要
我们报告了多层聚电解质包覆的金纳米棒（GNRs）作为多功能光学对比剂在癌细胞成像中的应用。GNRs 的表面修饰提高了它们的化学稳定性，并通过静电相互作用促进它们被癌细胞摄取。GNRs 的独特纵向表面等离子体共振特性使它们既适合作为“散射对比剂”，也适合作为“拉曼对比剂”。在我们的实验中，GNRs 在细胞中的染色进一步通过暗场显微镜和拉曼显微镜得到证实。我们的实验结果表明，GNRs 作为多功能“光学对比剂”在未来的体内动物成像中具有很大的潜力。
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