从辐射杂种基因型推断的人类遗传相互作用的全基因组图谱。
A genome-wide map of human genetic interactions inferred from radiation hybrid genotypes.
机构信息
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA.
出版信息
Genome Res. 2010 Aug;20(8):1122-32. doi: 10.1101/gr.104216.109. Epub 2010 May 27.
Abstract
Using radiation hybrid genotyping data, 99% of all possible gene pairs across the mammalian genome were tested for interactions based on co-retention frequencies higher (attraction) or lower (repulsion) than chance. Gene interaction networks constructed from six independent data sets overlapped strongly. Combining the data sets resulted in a network of more than seven million interactions, almost all attractive. This network overlapped with protein-protein interaction networks on multiple measures and also confirmed the relationship between essentiality and centrality. In contrast to other biological networks, the radiation hybrid network did not show a scale-free distribution of connectivity but was Gaussian-like, suggesting a closer approach to saturation. The radiation hybrid (RH) network constitutes a platform for understanding the systems biology of the mammalian cell.
摘要
利用辐射杂种基因分型数据，基于高于（吸引）或低于（排斥）偶然的共保留频率，对哺乳动物基因组中所有可能的基因对进行了 99%的相互作用测试。由六个独立数据集构建的基因相互作用网络强烈重叠。将数据集结合起来，得到了一个包含超过 700 万个相互作用的网络，几乎都是有吸引力的。该网络在多个指标上与蛋白质-蛋白质相互作用网络重叠，也证实了必需性和中心性之间的关系。与其他生物网络不同，辐射杂种网络没有表现出无标度连接性的分布，而是类高斯分布，这表明更接近饱和。辐射杂种（RH）网络为理解哺乳动物细胞的系统生物学提供了一个平台。
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