Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Inage, Chiba 263-8555, Japan.
J Radiat Res. 2010;51(4):355-64. doi: 10.1269/jrr.10016. Epub 2010 May 28.
In June 1994, the world's first clinical center offering carbon ion radiotherapy opened at the National Institute of Radiological Science (NIRS), Japan. Among several types of ion species, carbon ions were chosen for cancer therapy because they were judged to have the most optimal properties in terms of superior physical and biological characteristics. As of March 2010, 5,196 patients have been registered for carbon ion radiotherapy. Clinical results have shown that carbon ion radiotherapy has the potential to provide a sufficient radiation dose to the tumor, while having acceptable morbidity in the surrounding normal tissues. Tumors that appear to respond favorably to carbon ions include locally advanced tumors as well as histologically non-squamous cell tumor types such as adenocarcinoma, adenoid cystic carcinoma, malignant melanoma, hepatoma, and bone/soft tissue sarcoma. By taking advantage of the unique properties of carbon ions, treatment with small fractions within a short treatment period has been successfully carried out for a variety of tumors. This means that carbon ion radiotherapy can offer treatment for larger numbers of patients than is possible with other modalities over the same time period.
1994 年 6 月，世界上第一家提供碳离子放射治疗的临床中心在日本国立放射科学研究所（NIRS）成立。在几种类型的离子物种中，选择碳离子用于癌症治疗，是因为它们在优越的物理和生物学特性方面被认为具有最理想的特性。截至 2010 年 3 月，已有 5196 名患者登记接受碳离子放射治疗。临床结果表明，碳离子放射治疗有可能为肿瘤提供足够的辐射剂量，同时周围正常组织的发病率也可以接受。对碳离子反应良好的肿瘤包括局部晚期肿瘤以及组织学上非鳞状细胞肿瘤类型，如腺癌、腺样囊性癌、恶性黑色素瘤、肝癌和骨/软组织肉瘤。通过利用碳离子的独特特性，已经成功地对各种肿瘤进行了短疗程的小剂量分次治疗。这意味着，与其他治疗方式相比，碳离子放射治疗在相同的时间内可以为更多的患者提供治疗。
