三甲基氯化锡体外诱导人外周血淋巴细胞染色体畸变的频率：与供体年龄的关系
Frequency of chromosome aberrations induced by trimethyltin chloride in human peripheral blood lymphocytes in vitro: related to age of donors.
作者信息
Ghosh B B, Talukder G, Sharma A
机构信息
Human Genetics Unit, Centre of Advanced Study, Cell and Chromosome Research, Calcutta, India.
出版信息
Mech Ageing Dev. 1991 Feb;57(2):125-37. doi: 10.1016/0047-6374(91)90029-y.
Human peripheral blood lymphocytes of healthy male and female individuals of different age groups were treated with two aqueous doses (0.5 microgram and 1.0 microgram) of trimethyltin chloride in mitogen stimulated and serum supplemented culture medium for 72 h at 37 degrees C. Chromatid and chromosome types of aberrations were observed to be increased in both treated sets in all age groups. Significant variations were observed between age groups (P less than 0.001) and between experimental sets (P less than 0.001). Moreover, interaction of chemical and donors age was statistically highly significant (P less than 0.05-P less than 0.001). However, no linear correlation between the increase of donor's age and aberrations was observed.
将来自不同年龄组的健康男性和女性个体的人外周血淋巴细胞，在有丝分裂原刺激且添加血清的培养基中，用两剂水相氯化三甲基锡（0.5微克和1.0微克）在37℃处理72小时。在所有年龄组的两个处理组中，均观察到染色单体和染色体类型的畸变增加。在年龄组之间（P<0.001）以及实验组之间（P<0.001）观察到显著差异。此外，化学物质与供体年龄的相互作用在统计学上具有高度显著性（P<0.05 - P<0.001）。然而，未观察到供体年龄增加与畸变之间的线性相关性。
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