LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear & Throat Hospital, New York, New York, USA.
Retina. 2010 Jul-Aug;30(7):1104-12. doi: 10.1097/IAE.0b013e3181d87ecb.
The purpose of this study was to characterize retinal manifestations of optic pit maculopathy using high-resolution optical coherence tomography.
Consecutive patients with optic pit maculopathy, diagnosed by their typical appearance by ophthalmoscopy, were imaged by color fundus photography and optical coherence tomography. The location and characteristics of any fluid within and under the retina were determined.
The mean age of the 16 patients (7 women) was 35.9 years (standard deviation: 18.5 years). The visual acuity ranged from 20/20 to 20/1000 (median, 20/200). Retinal detachment was found in 11 eyes (69%), intraretinal fluid in the outer nuclear layer in 15 eyes (94%), in the inner nuclear layer in 13 eyes (81%), in the ganglion cell layer in 7 eyes (44%), and in the subinternal limiting membrane space in 2 eyes (13%). An outer layer hole was identified in only 3 of 11 eyes (27%) with retinal detachment.
Fluid from the optic pit can go directly to the subinternal limiting membrane space, ganglion cell layer, inner nuclear layer, outer nuclear layer, or the subretinal space, although the outer nuclear layer is most commonly affected. An outer layer hole appears not to be common in optic pit maculopathy.
本研究旨在通过高分辨率光相干断层扫描（OCT）来描述视盘小凹黄斑病变的视网膜表现。
对经眼底镜检查诊断为视盘小凹黄斑病变的连续患者进行眼底彩色照相和 OCT 成像。确定视网膜内和视网膜下任何液体的位置和特征。
16 名患者（7 名女性）的平均年龄为 35.9 岁（标准差：18.5 岁）。视力从 20/20 到 20/1000（中位数，20/200）不等。11 只眼（69%）发现视网膜脱离，15 只眼（94%）在外核层出现视网膜内液，13 只眼（81%）在内核层出现视网膜内液，7 只眼（44%）在神经节细胞层出现视网膜内液，2 只眼（13%）在内界膜下空间出现视网膜内液。在 11 只（27%）出现视网膜脱离的眼中仅发现 3 只（27%）存在外核层裂孔。
尽管外核层最常受累，但视盘小凹的液体可直接进入内界膜下空间、神经节细胞层、内核层、外核层或视网膜下间隙。视盘小凹黄斑病变中似乎并不常见外核层裂孔。
