Zeytinli Bahçe caddesi, Tip Fakültesi Hastanesi, Klinik Mikrobiyoloji ve Infeksiyon Hastaliklari, Mersin Universitesi, 33079, Mersin, Turkey.
Mycopathologia. 2010 Oct;170(4):263-8. doi: 10.1007/s11046-010-9322-5. Epub 2010 Jun 4.
We aimed to asses possible clinically significant differences between C. parapsilosis and other candida species candidemia receiving care in the intensive care unit (ICU) setting.
The study included 118 adult patients diagnosed as candidemia after admission to the ICU of a university hospital between January 2004 and December 2009. Data about demographic characteristics, underlying diseases, and risk factors for ICU-related candidemia were collected.
During the study period, 118 patients with candidemia were identified among 2,853 patients admitted into the ICU. Candidemia was seen in 41.4 cases per 1,000 ICU admissions. The overall incidence of candidemia in ICU patients during the study period was 2.09 per 1,000 hospital admissions. Of the isolates, 18.6% were C. albicans and 81.4% were C. non-albicans. The species most frequently isolated was C. parapsilosis (66.1%, 78/118). The distribution of other Candida spp. was as follows: 15 had C. tropicalis (12.7%) and 3 had C. glabrata (2.5%). By Statistical analysis, when patients with candidemia who had C. parapsilosis were compared with other Candida spp., the following factors were found to be significantly associated with C. parapsilosis fungemia; intravascular catheters (p = 0.008), malignity (p = 0.049) and age (p = 0.039). Relationship was found between C. tropicalis and hematologic malignancies (p = 0.001).
When infections with a high mortality such as candidemia is suspected in critically ill patients, it is important to know local risk factors and epidemiological distributions of causative agents in selection of empirical and effective antifungal treatment.
我们旨在评估 ICU 环境中接受治疗的近平滑念珠菌与其他念珠菌属种念珠菌血症之间可能存在的临床显著差异。
该研究纳入了 2004 年 1 月至 2009 年 12 月期间在一所大学医院 ICU 住院的 118 例成人念珠菌血症患者。收集了有关人口统计学特征、基础疾病和 ICU 相关念珠菌血症危险因素的数据。
在研究期间，在 ICU 住院的 2853 例患者中发现了 118 例念珠菌血症患者。念珠菌血症的发病率为每 1000 例 ICU 入院 41.4 例。在研究期间，ICU 患者念珠菌血症的总发生率为每 1000 例住院患者 2.09 例。在分离株中，18.6%为白念珠菌，81.4%为非白念珠菌。最常分离到的菌种为近平滑念珠菌（66.1%，78/118）。其他念珠菌属的分布情况如下：15 株为热带念珠菌（12.7%），3 株为光滑念珠菌（2.5%）。通过统计学分析，当将患有近平滑念珠菌血症的患者与其他念珠菌属种进行比较时，发现以下因素与近平滑念珠菌血症显著相关：血管内导管（p = 0.008）、恶性肿瘤（p = 0.049）和年龄（p = 0.039）。发现热带念珠菌与血液恶性肿瘤之间存在关系（p = 0.001）。
在怀疑患有危重患者感染等死亡率较高的念珠菌血症时，了解当地的危险因素和病原体的流行病学分布对于选择经验性和有效的抗真菌治疗非常重要。
