Department of Orthopaedics, Teaching Hospital, Palacký University, Olomouc 77520, Czech Republic.
J Biomed Mater Res B Appl Biomater. 2010 Jul;94(1):171-7. doi: 10.1002/jbm.b.31638.
The most critical factor in the development of periprosthetic osteolysis (OL) in total hip arthroplasty (THA) is the biological reaction to wear debris. This reaction is dependent, in part, on the size and concentration of particles, which are determined predominantly by the polyethylene (PE) wear rate. This implies that the risk for developing OL and prosthesis failure can be estimated from wear measurements. We developed a computational algorithm for calculating the total number of PE particles for volumetric wear when particle size and distribution are known. We found that: (i) total number of PE wear particles decreases up to 5 orders of magnitude if the average size of particles increases and the total volumetric wear remains constant; (ii) total amount of PE wear particles decreases up to 4 orders of magnitude if the width of the distribution increases and total volumetric wear remains constant; (iii) for the same volumetric wear, the number of particles significantly decreases/increases with the increase/decrease in their average size and range. These findings suggest that the risk for the development of OL in THA cannot be simply estimated from the volumetric wear alone.
在全髋关节置换术（THA）中，假体周围骨溶解（OL）发展的最关键因素是对磨损颗粒的生物反应。这种反应部分取决于颗粒的大小和浓度，而颗粒大小和浓度主要由聚乙烯（PE）磨损率决定。这意味着可以通过磨损测量来估计发生 OL 和假体失效的风险。我们开发了一种计算算法，用于计算已知粒径和分布时体积磨损的总 PE 颗粒数。我们发现：（i）如果颗粒的平均尺寸增加而总体积磨损保持不变，则 PE 磨损颗粒的总数减少多达 5 个数量级；（ii）如果分布的宽度增加而总体积磨损保持不变，则 PE 磨损颗粒的总量减少多达 4 个数量级；（iii）对于相同的体积磨损，颗粒的数量随着其平均尺寸和范围的增加/减少而显著减少/增加。这些发现表明，THA 中 OL 发展的风险不能仅从体积磨损来简单估计。
