School of Science, University of Greenwich, Kent, UK.
Crit Rev Biotechnol. 2010 Dec;30(4):283-301. doi: 10.3109/07388551.2010.487184. Epub 2010 Jun 8.
Semiconductor quantum dots (QDs) synthesized by metal ions and colloid stabilizers have been explored as promising probes in advanced imaging techniques, tumor diagnostic agents, and drug delivery systems. The ability to modulate QDs surface chemistry through particle--shape control, surface coating, and surface functionalization-has rendered them a valuable tool in biological sciences. The tremendous advances in nanotechnology revealed the unique properties of QD crystals in both in vitro and in vivo conditions. In this review, we summarize the recent trends in QD synthesis, surface modification, and biological applications particularly for cancer targeting and treatment.
半导体量子点（QDs）是由金属离子和胶体稳定剂合成的，已被探索作为先进成像技术、肿瘤诊断剂和药物输送系统中的有前途的探针。通过控制颗粒形状、表面涂层和表面功能化来调节 QDs 表面化学的能力，使它们成为生物科学中非常有价值的工具。纳米技术的巨大进步揭示了 QD 晶体在体外和体内条件下的独特性质。在这篇综述中，我们总结了 QD 合成、表面修饰和生物应用的最新趋势，特别是在癌症靶向和治疗方面。
